TY  - JOUR
AU  - Rothwell, Joseph A
AU  - Bešević, Jelena
AU  - Dimou, Niki
AU  - Breeur, Marie
AU  - Murphy, Neil
AU  - Jenab, Mazda
AU  - Wedekind, Roland
AU  - Viallon, Vivian
AU  - Ferrari, Pietro
AU  - Achaintre, David
AU  - Gicquiau, Audrey
AU  - Rinaldi, Sabina
AU  - Scalbert, Augustin
AU  - Huybrechts, Inge
AU  - Prehn, Cornelia
AU  - Adamski, Jerzy
AU  - Cross, Amanda J
AU  - Keun, Hector
AU  - Chadeau-Hyam, Marc
AU  - Boutron-Ruault, Marie-Christine
AU  - Overvad, Kim
AU  - Dahm, Christina C
AU  - Nøst, Therese Haugdahl
AU  - Sandanger, Torkjel M
AU  - Skeie, Guri
AU  - Zamora-Ros, Raul
AU  - Tsilidis, Kostas K
AU  - Eichelmann, Fabian
AU  - Schulze, Matthias B
AU  - van Guelpen, Bethany
AU  - Vidman, Linda
AU  - Sánchez, Maria-José
AU  - Amiano, Pilar
AU  - Ardanaz, Eva
AU  - Smith-Byrne, Karl
AU  - Travis, Ruth
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Derksen, Jeroen W G
AU  - Colorado-Yohar, Sandra
AU  - Tumino, Rosario
AU  - Bueno-de-Mesquita, Bas
AU  - Vineis, Paolo
AU  - Palli, Domenico
AU  - Pasanisi, Fabrizio
AU  - Eriksen, Anne Kirstine
AU  - Tjønneland, Anne
AU  - Severi, Gianluca
AU  - Gunter, Marc J
TI  - Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
JO  - BMC medicine
VL  - 21
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2023-00427
SP  - 80
PY  - 2023
AB  - Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95
KW  - Humans
KW  - Amino Acids
KW  - Glutamine
KW  - Histidine
KW  - Biological Specimen Banks
KW  - Prospective Studies
KW  - Colorectal Neoplasms: epidemiology
KW  - United Kingdom: epidemiology
KW  - Amino acids (Other)
KW  - Colorectal cancer (Other)
KW  - Glutamine (Other)
KW  - Histidine (Other)
KW  - Amino Acids (NLM Chemicals)
KW  - Glutamine (NLM Chemicals)
KW  - Histidine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36855092
DO  - DOI:10.1186/s12916-023-02739-4
UR  - https://inrepo02.dkfz.de/record/274081
ER  -