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@ARTICLE{Rothwell:274081,
      author       = {J. A. Rothwell and J. Bešević and N. Dimou and M. Breeur
                      and N. Murphy and M. Jenab and R. Wedekind and V. Viallon
                      and P. Ferrari and D. Achaintre and A. Gicquiau and S.
                      Rinaldi and A. Scalbert and I. Huybrechts and C. Prehn and
                      J. Adamski and A. J. Cross and H. Keun and M. Chadeau-Hyam
                      and M.-C. Boutron-Ruault and K. Overvad and C. C. Dahm and
                      T. H. Nøst and T. M. Sandanger and G. Skeie and R.
                      Zamora-Ros and K. K. Tsilidis and F. Eichelmann and M. B.
                      Schulze and B. van Guelpen and L. Vidman and M.-J. Sánchez
                      and P. Amiano and E. Ardanaz and K. Smith-Byrne and R.
                      Travis and V. Katzke$^*$ and R. Kaaks$^*$ and J. W. G.
                      Derksen and S. Colorado-Yohar and R. Tumino and B.
                      Bueno-de-Mesquita and P. Vineis and D. Palli and F. Pasanisi
                      and A. K. Eriksen and A. Tjønneland and G. Severi and M. J.
                      Gunter},
      title        = {{C}irculating amino acid levels and colorectal cancer risk
                      in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition and {UK} {B}iobank cohorts.},
      journal      = {BMC medicine},
      volume       = {21},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-00427},
      pages        = {80},
      year         = {2023},
      abstract     = {Amino acid metabolism is dysregulated in colorectal cancer
                      patients; however, it is not clear whether pre-diagnostic
                      levels of amino acids are associated with subsequent risk of
                      colorectal cancer. We investigated circulating levels of
                      amino acids in relation to colorectal cancer risk in the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC) and UK Biobank cohorts.Concentrations of 13-21 amino
                      acids were determined in baseline fasting plasma or serum
                      samples in 654 incident colorectal cancer cases and 654
                      matched controls in EPIC. Amino acids associated with
                      colorectal cancer risk following adjustment for the false
                      discovery rate (FDR) were then tested for associations in
                      the UK Biobank, for which measurements of 9 amino acids were
                      available in 111,323 participants, of which 1221 were
                      incident colorectal cancer cases.Histidine levels were
                      inversely associated with colorectal cancer risk in EPIC
                      (odds ratio [OR] 0.80 per standard deviation [SD], $95\%$
                      confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in
                      UK Biobank (HR 0.93 per SD, $95\%$ CI 0.87-0.99,
                      P-value=0.03). Glutamine levels were borderline inversely
                      associated with colorectal cancer risk in EPIC (OR 0.85 per
                      SD, $95\%$ CI 0.75-0.97, FDR P-value=0.08) and similarly in
                      UK Biobank (HR 0.95, $95\%$ CI 0.89-1.01, P=0.09) In both
                      cohorts, associations changed only minimally when cases
                      diagnosed within 2 or 5 years of follow-up were
                      excluded.Higher circulating levels of histidine were
                      associated with a lower risk of colorectal cancer in two
                      large prospective cohorts. Further research to ascertain the
                      role of histidine metabolism and potentially that of
                      glutamine in colorectal cancer development is warranted.},
      keywords     = {Humans / Amino Acids / Glutamine / Histidine / Biological
                      Specimen Banks / Prospective Studies / Colorectal Neoplasms:
                      epidemiology / United Kingdom: epidemiology / Amino acids
                      (Other) / Colorectal cancer (Other) / Glutamine (Other) /
                      Histidine (Other) / Amino Acids (NLM Chemicals) / Glutamine
                      (NLM Chemicals) / Histidine (NLM Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36855092},
      doi          = {10.1186/s12916-023-02739-4},
      url          = {https://inrepo02.dkfz.de/record/274081},
}