TY  - JOUR
AU  - Mascalchi, Mario
AU  - Romei, Chiara
AU  - Marzi, Chiara
AU  - Diciotti, Stefano
AU  - Picozzi, Giulia
AU  - Pistelli, Francesco
AU  - Zappa, Marco
AU  - Paci, Eugenio
AU  - Carozzi, Francesca
AU  - Gorini, Giuseppe
AU  - Falaschi, Fabio
AU  - Deliperi, Anna Lisa
AU  - Camiciottoli, Gianna
AU  - Carrozzi, Laura
AU  - Puliti, Donella
TI  - Pulmonary emphysema and coronary artery calcifications at baseline LDCT and long-term mortality in smokers and former smokers of the ITALUNG screening trial.
JO  - European radiology
VL  - 33
IS  - 5
SN  - 0938-7994
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2023-00428
SP  - 3115-3123
PY  - 2023
N1  - #EA:C020# / 2023 May;33(5):3115-3123
AB  - Cardiovascular disease (CVD), lung cancer (LC), and respiratory diseases are main causes of death in smokers and former smokers undergoing low-dose computed tomography (LDCT) for LC screening. We assessed whether quantification of pulmonary emphysematous changes at baseline LDCT has a predictive value concerning long-term mortality.In this longitudinal study, we assessed pulmonary emphysematous changes with densitometry (volume corrected relative area below - 950 Hounsfield units) and coronary artery calcifications (CAC) with a 0-3 visual scale in baseline LDCT of 524 participants in the ITALUNG trial and analyzed their association with mortality after 13.6 years of follow-up using conventional statistics and a machine learning approach.Pulmonary emphysematous changes were present in 32.3
KW  - Cardiovascular disease (Other)
KW  - Cause of death (Other)
KW  - Lung neoplasm (Other)
KW  - Pulmonary emphysema (Other)
KW  - Smokers (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36854875
DO  - DOI:10.1007/s00330-023-09504-4
UR  - https://inrepo02.dkfz.de/record/274082
ER  -