000274083 001__ 274083
000274083 005__ 20240229162318.0
000274083 0247_ $$2doi$$a10.3389/fimmu.2023.1114368
000274083 0247_ $$2pmid$$apmid:36860867
000274083 0247_ $$2pmc$$apmc:PMC9969884
000274083 037__ $$aDKFZ-2023-00429
000274083 041__ $$aEnglish
000274083 082__ $$a610
000274083 1001_ $$aObermayer, Benedikt$$b0
000274083 245__ $$aSingle-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation.
000274083 260__ $$aLausanne$$bFrontiers Media$$c2023
000274083 3367_ $$2DRIVER$$aarticle
000274083 3367_ $$2DataCite$$aOutput Types/Journal article
000274083 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1677840743_22110
000274083 3367_ $$2BibTeX$$aARTICLE
000274083 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000274083 3367_ $$00$$2EndNote$$aJournal Article
000274083 520__ $$aThe critical balance between intended and adverse effects in allogeneic hematopoietic stem cell transplantation (alloHSCT) depends on the fate of individual donor T-cells. To this end, we tracked αβT-cell clonotypes during stem cell mobilization treatment with granulocyte-colony stimulating factor (G-CSF) in healthy donors and for six months during immune reconstitution after transfer to transplant recipients. More than 250 αβT-cell clonotypes were tracked from donor to recipient. These clonotypes consisted almost exclusively of CD8+ effector memory T cells (CD8TEM), which exhibited a different transcriptional signature with enhanced effector and cytotoxic functions compared to other CD8TEM. Importantly, these distinct and persisting clonotypes could already be delineated in the donor. We confirmed these phenotypes on the protein level and their potential for selection from the graft. Thus, we identified a transcriptional signature associated with persistence and expansion of donor T-cell clonotypes after alloHSCT that may be exploited for personalized graft manipulation strategies in future studies.
000274083 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000274083 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000274083 650_7 $$2Other$$aT-cells
000274083 650_7 $$2Other$$aallogeneic HSCT
000274083 650_7 $$2Other$$aclonal tracking
000274083 650_7 $$2Other$$aleukemia
000274083 650_7 $$2Other$$ascRNAseq
000274083 650_7 $$2Other$$atransplantation
000274083 7001_ $$aKeilholz, Luisa$$b1
000274083 7001_ $$aConrad, Thomas$$b2
000274083 7001_ $$aFrentsch, Marco$$b3
000274083 7001_ $$aBlau, Igor-Wolfgang$$b4
000274083 7001_ $$aVuong, Lam$$b5
000274083 7001_ $$aLesch, Stella$$b6
000274083 7001_ $$aMovasshagi, Kamran$$b7
000274083 7001_ $$aTietze-Stolley, Carola$$b8
000274083 7001_ $$aLoyal, Lucie$$b9
000274083 7001_ $$aHenze, Larissa$$b10
000274083 7001_ $$aPenack, Olaf$$b11
000274083 7001_ $$aStervbo, Ulrik$$b12
000274083 7001_ $$aBabel, Nina$$b13
000274083 7001_ $$0P:(DE-He78)a5ec4e2fef99022a37a6b07c2fdd6325$$aHaas, Simon$$b14$$udkfz
000274083 7001_ $$aBeule, Dieter$$b15
000274083 7001_ $$0P:(DE-HGF)0$$aBullinger, Lars$$b16
000274083 7001_ $$aWittenbecher, Friedrich$$b17
000274083 7001_ $$0P:(DE-HGF)0$$aNa, Il-Kang$$b18
000274083 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2023.1114368$$gVol. 14, p. 1114368$$p1114368$$tFrontiers in immunology$$v14$$x1664-3224$$y2023
000274083 909CO $$ooai:inrepo02.dkfz.de:274083$$pVDB
000274083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a5ec4e2fef99022a37a6b07c2fdd6325$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000274083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000274083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000274083 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000274083 9141_ $$y2023
000274083 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-05-11T10:28:02Z
000274083 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-05-11T10:28:02Z
000274083 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-05-11T10:28:02Z
000274083 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-23
000274083 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-23
000274083 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2022-11-23
000274083 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2022-11-23
000274083 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT IMMUNOL : 2022$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2021-05-11T10:28:02Z
000274083 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-26
000274083 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bFRONT IMMUNOL : 2022$$d2023-10-26
000274083 9201_ $$0I:(DE-He78)BE01-20160331$$kBE01$$lDKTK BE zentral$$x0
000274083 980__ $$ajournal
000274083 980__ $$aVDB
000274083 980__ $$aI:(DE-He78)BE01-20160331
000274083 980__ $$aUNRESTRICTED