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@ARTICLE{Molostvov:274134,
      author       = {G. Molostvov and M. Gachechiladze and A. M. Shaaban and S.
                      Hayward and I. Dean and I. H. K. Dias and N. Badr and I.
                      Danial and F. Mohammed and V. Novitskaya and L. Paniushkina
                      and V. Speirs and A. Hanby and I. Nazarenko$^*$ and D. R.
                      Withers and S. van Laere and H. M. Long and F.
                      Berditchevski},
      title        = {{T}span6 stimulates the chemoattractive potential of breast
                      cancer cells for {B} cells in an {EV}- and {LXR}-dependent
                      manner.},
      journal      = {Cell reports},
      volume       = {42},
      number       = {3},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00444},
      pages        = {112207},
      year         = {2023},
      abstract     = {The immune microenvironment in breast cancer (BCa) is
                      controlled by a complex network of communication between
                      various cell types. Here, we find that recruitment of B
                      lymphocytes to BCa tissues is controlled via mechanisms
                      associated with cancer cell-derived extracellular vesicles
                      (CCD-EVs). Gene expression profiling identifies the Liver X
                      receptor (LXR)-dependent transcriptional network as a key
                      pathway that controls both CCD-EVs-induced migration of B
                      cells and accumulation of B cells in BCa tissues. The
                      increased accumulation oxysterol ligands for LXR (i.e.,
                      25-hydroxycholesterol and 27-hydroxycholesterol) in CCD-EVs
                      is regulated by the tetraspanin 6 (Tspan6). Tspan6
                      stimulates the chemoattractive potential of BCa cells for B
                      cells in an EV- and LXR-dependent manner. These results
                      demonstrate that tetraspanins control intercellular
                      trafficking of oxysterols via CCD-EVs. Furthermore,
                      tetraspanin-dependent changes in the oxysterol composition
                      of CCD-EVs and the LXR signaling axis play a key role in
                      specific changes in the tumor immune microenvironment.},
      keywords     = {B cells (Other) / CP: Cancer (Other) / LXR (Other) / breast
                      cancer (Other) / oxysterols (Other) / tetraspanins (Other) /
                      tumor microenvironment (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36867531},
      doi          = {10.1016/j.celrep.2023.112207},
      url          = {https://inrepo02.dkfz.de/record/274134},
}