TY  - JOUR
AU  - Hemminki, Kari
AU  - Li, Xinjun
AU  - Försti, Asta
AU  - Eng, Charis
TI  - Are population level familial risks and germline genetics meeting each other?
JO  - Hereditary cancer in clinical practice
VL  - 21
IS  - 1
SN  - 1731-2302
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2023-00463
SP  - 3
PY  - 2023
N1  - #EA:C020#
AB  - Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family members since the start of national cancer registration in 1958. The database allows estimation of familial risks, ages of cancer onset and the proportion of familial cancer in different family constellations. Here, we review the proportion of familial cancer for all common cancers and specify them based on the number of affected individuals. With the exception of a few cancers, age of onset of familial cancer is not different from all cancers combined. The highest proportions of familial cancer were found for prostate (26.4
KW  - Familial proportion (Other)
KW  - Familial risk (Other)
KW  - Family-Cancer Database (Other)
KW  - High-risk families (Other)
KW  - Nation-wide study (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36882784
DO  - DOI:10.1186/s13053-023-00247-3
UR  - https://inrepo02.dkfz.de/record/274161
ER  -