TY  - JOUR
AU  - Bhattacharya, Shreya
AU  - Maupin, Alec Jacob
AU  - Schlosser, Anders Grønnegaard
AU  - Füchtbauer, Ernst-Martin
AU  - Gloria, Yamel Cardona
AU  - Weber, Alexander
AU  - Holmskov, Uffe
AU  - Moeller, Jesper Bonnet
AU  - Templeton, Steven P
TI  - The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells.
JO  - PLOS ONE
VL  - 18
IS  - 3
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DKFZ-2023-00473
SP  - e0282347 -
PY  - 2023
AB  - Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles.
LB  - PUB:(DE-HGF)16
C6  - pmid:36888604
DO  - DOI:10.1371/journal.pone.0282347
UR  - https://inrepo02.dkfz.de/record/274178
ER  -