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@ARTICLE{Bhattacharya:274178,
      author       = {S. Bhattacharya and A. J. Maupin and A. G. Schlosser and
                      E.-M. Füchtbauer and Y. C. Gloria and A. Weber$^*$ and U.
                      Holmskov and J. B. Moeller and S. P. Templeton},
      title        = {{T}he role of {FIBCD}1 in response to {A}spergillus
                      fumigatus in lung epithelial cells.},
      journal      = {PLOS ONE},
      volume       = {18},
      number       = {3},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2023-00473},
      pages        = {e0282347 -},
      year         = {2023},
      abstract     = {Chitin, a polysaccharide, is ubiquitously found in nature
                      and has been known to be an active immunogen in mammals, and
                      interacts with Toll-like, mannose and glucan receptors, to
                      induce cytokine and chemokine secretions. FIBCD1 is a
                      tetrameric type II transmembrane endocytic vertebrate
                      receptor that binds chitin, is found in human lung
                      epithelium and modulates lung epithelial inflammatory
                      responses to A. fumigatus cell wall polysaccharides. We
                      previously reported the detrimental role of FIBCD1 in a
                      murine model of pulmonary invasive aspergillosis. However,
                      the effect that chitin and chitin-containing A. fumigatus
                      conidia exerts on lung epithelium following exposure through
                      FIBCD1 is not yet fully explored. Using both in vitro and in
                      vivo strategies, we examined how lung and lung epithelial
                      gene expression are modified after exposure to fungal
                      conidia or chitin fragments in the presence or absence of
                      FIBCD1. FIBCD1 expression was associated with a decrease in
                      inflammatory cytokines with increasing size of chitin
                      (dimer-oligomer). Thus, our results demonstrate that FIBCD1
                      expression modulates cytokine and chemokine expression in
                      response to A. fumigatus conidia that is modified by the
                      presence of chitin particles.},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36888604},
      doi          = {10.1371/journal.pone.0282347},
      url          = {https://inrepo02.dkfz.de/record/274178},
}