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@ARTICLE{Langhans:274180,
      author       = {M. Langhans and I. Popp$^*$ and A.-L. Grosu$^*$ and N.
                      Shusharina and H. Binder and D. Baltas$^*$ and T. Bortfeld},
      title        = {{R}ecurrence {A}nalysis of {G}lioblastoma {C}ases {B}ased
                      on {D}istance and {D}ose {I}nformation.},
      journal      = {Radiotherapy and oncology},
      volume       = {183},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-00475},
      pages        = {109600},
      year         = {2023},
      note         = {2023 Jun;183:109600},
      abstract     = {Radiation therapy for glioblastoma (GBM) typically involves
                      large target volumes. The aim of this study was to examine
                      the recurrence pattern of GBM following modern
                      radiochemotherapy according to EORTC guidelines and provide
                      dose and distance information for the choice of optimal
                      target volume margins.In this study, the recurrences of 97
                      GBM patients, treated with radiochemotherapy from 2013 to
                      2017 at the Medical Center- University of Freiburg, Germany
                      were analysed. Dose and distance based metrices were used to
                      derive recurrence patterns.The majority of recurrences (75
                      $\%)$ occurred locally within the primary tumor area.
                      Smaller GTVs had a higher rate of distant recurrences.
                      Larger treated volumes did not show a clinical benefit
                      regarding progression- free and overall survival.The
                      identified recurrence pattern suggests that adjustments or
                      reductions in target volume margins are feasible and could
                      result in similar survival rates, potentially combined with
                      a lower risk of side effects.},
      keywords     = {glioblastoma (Other) / radiotherapy (Other) / recurrence
                      (Other) / target volume (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36889597},
      doi          = {10.1016/j.radonc.2023.109600},
      url          = {https://inrepo02.dkfz.de/record/274180},
}