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000274204 1001_ $$0P:(DE-He78)72642b84997c1dedbf3e62dd57dede80$$aSchifflers, Christoph$$b0$$eFirst author$$udkfz
000274204 245__ $$aDevelopment of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice.
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000274204 520__ $$aHead and neck squamous cell carcinomas (HNSCC) caused by infections with high-risk human papillomaviruses (HPV) are responsible for an increasing number of head and neck cancers, particularly in the oropharynx. Despite the significant biological differences between HPV-driven and HPV-negative HNSCC, treatment strategies are similar and not HPV targeted. HPV-driven HNSCC are known to be more sensitive to treatment, particularly to radiotherapy, which is at least partially due to HPV-induced immunogenicity. The development of novel therapeutic strategies that are specific for HPV-driven cancers requires tumor models that reflect as closely as possible the characteristics and complexity of human tumors and their response to treatment. Current HPV-positive cancer models lack one or more hallmarks of their human counterpart. This study presents the development of a new HPV16 oncoprotein-dependent tumor model in MHC-humanized mice, modeling the major biologic features of HPV-driven tumors and presenting HLA-A2-restricted HPV16 epitopes. Furthermore, this model was developed to be orthotopic (base of tongue). Thus, it also reflects the correct tumor microenvironment of HPV-driven HNSCC. The cancer cells are implanted in a manner that allows the exact control of the anatomical location of the developing tumor, thereby homogenizing tumor growth. In conclusion, the new model is suited to study HPV16-specific therapeutic vaccinations and other immunotherapies, as well as tumor-targeted interventions, such as surgery or radiotherapy, or a combination of all these modalities.
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000274204 650_7 $$2Other$$ahead and neck squamous cell carcinoma
000274204 650_7 $$2Other$$ahuman papillomavirus
000274204 650_7 $$2Other$$aorthotopic tumor model
000274204 7001_ $$0P:(DE-He78)e03b110ee83e48c1f9c099c723c76e7e$$aZottnick, Samantha$$b1$$udkfz
000274204 7001_ $$0P:(DE-He78)1dfe5fa05989d8b5eeb8bd098e2f1c1f$$aFörster, Jonas$$b2$$udkfz
000274204 7001_ $$0P:(DE-He78)2d912f097c2da0d6c989134e4e9aec18$$aKruse, Sebastian$$b3
000274204 7001_ $$0P:(DE-He78)9d9fc8bc93a08a610c9f4759bbf86bd7$$aYang, Ruwen$$b4
000274204 7001_ $$0P:(DE-He78)65980361d4934ac5be3a99a4b9cea356$$aWiethoff, Hendrik$$b5$$udkfz
000274204 7001_ $$0P:(DE-He78)3391c5ad790ea5359189d11f073fb103$$aBozza, Matthias$$b6
000274204 7001_ $$0P:(DE-He78)97468f1980416a4376b44e701d25f24b$$aHoppe-Seyler, Karin$$b7$$udkfz
000274204 7001_ $$0P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5$$aHeikenwälder, Mathias$$b8$$udkfz
000274204 7001_ $$0P:(DE-He78)15dff5647002b4dcfe892b251cd14b62$$aHarbottle, Richard P$$b9$$udkfz
000274204 7001_ $$00000-0002-9169-1294$$aMichiels, Carine$$b10
000274204 7001_ $$0P:(DE-He78)3743a1b712edca2ffa829b7096d7037e$$aRiemer, Angelika$$b11$$eLast author$$udkfz
000274204 773__ $$0PERI:(DE-600)2695572-6$$a10.3390/pathogens12020188$$gVol. 12, no. 2, p. 188 -$$n2$$p188$$tPathogens$$v12$$x2076-0817$$y2023
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