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@ARTICLE{Schifflers:274204,
      author       = {C. Schifflers$^*$ and S. Zottnick$^*$ and J. Förster$^*$
                      and S. Kruse$^*$ and R. Yang$^*$ and H. Wiethoff$^*$ and M.
                      Bozza$^*$ and K. Hoppe-Seyler$^*$ and M. Heikenwälder$^*$
                      and R. P. Harbottle$^*$ and C. Michiels and A. Riemer$^*$},
      title        = {{D}evelopment of an {O}rthotopic {HPV}16-{D}ependent {B}ase
                      of {T}ongue {T}umor {M}odel in {MHC}-{H}umanized {M}ice.},
      journal      = {Pathogens},
      volume       = {12},
      number       = {2},
      issn         = {2076-0817},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00490},
      pages        = {188},
      year         = {2023},
      note         = {#EA:F130#LA:F130#},
      abstract     = {Head and neck squamous cell carcinomas (HNSCC) caused by
                      infections with high-risk human papillomaviruses (HPV) are
                      responsible for an increasing number of head and neck
                      cancers, particularly in the oropharynx. Despite the
                      significant biological differences between HPV-driven and
                      HPV-negative HNSCC, treatment strategies are similar and not
                      HPV targeted. HPV-driven HNSCC are known to be more
                      sensitive to treatment, particularly to radiotherapy, which
                      is at least partially due to HPV-induced immunogenicity. The
                      development of novel therapeutic strategies that are
                      specific for HPV-driven cancers requires tumor models that
                      reflect as closely as possible the characteristics and
                      complexity of human tumors and their response to treatment.
                      Current HPV-positive cancer models lack one or more
                      hallmarks of their human counterpart. This study presents
                      the development of a new HPV16 oncoprotein-dependent tumor
                      model in MHC-humanized mice, modeling the major biologic
                      features of HPV-driven tumors and presenting
                      HLA-A2-restricted HPV16 epitopes. Furthermore, this model
                      was developed to be orthotopic (base of tongue). Thus, it
                      also reflects the correct tumor microenvironment of
                      HPV-driven HNSCC. The cancer cells are implanted in a manner
                      that allows the exact control of the anatomical location of
                      the developing tumor, thereby homogenizing tumor growth. In
                      conclusion, the new model is suited to study HPV16-specific
                      therapeutic vaccinations and other immunotherapies, as well
                      as tumor-targeted interventions, such as surgery or
                      radiotherapy, or a combination of all these modalities.},
      keywords     = {head and neck squamous cell carcinoma (Other) / human
                      papillomavirus (Other) / orthotopic tumor model (Other)},
      cin          = {F130 / F030 / F190 / F160 / F065 / F180},
      ddc          = {610},
      cid          = {I:(DE-He78)F130-20160331 / I:(DE-He78)F030-20160331 /
                      I:(DE-He78)F190-20160331 / I:(DE-He78)F160-20160331 /
                      I:(DE-He78)F065-20160331 / I:(DE-He78)F180-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36839460},
      pmc          = {pmc:PMC9958775},
      doi          = {10.3390/pathogens12020188},
      url          = {https://inrepo02.dkfz.de/record/274204},
}