%0 Journal Article
%A Kniess, Torsten
%A Zessin, Jörg
%A Mäding, Peter
%A Kuchar, Manuela
%A Kiss, Oliver
%A Kopka, Klaus
%T Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist's perspective.
%J EJNMMI radiopharmacy and chemistry
%V 8
%N 1
%@ 2365-421X
%C [Heidelberg]
%I SpringerOpen
%M DKFZ-2023-00495
%P 5
%D 2023
%X [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells. Since hypoxia is prevalent in solid tumors, [18F]FMISO is in clinical application for decades to explore oxygen demand in cancer cells and the resulting impact on radiotherapy and chemotherapy.Since the introduction of [18F]FMISO as positron emission tomography imaging agent in 1986, a variety of radiosynthesis procedures for the production of this hypoxia tracer has been developed. This paper gives a brief overview on [18F]FMISO radiosyntheses published so far from its introduction until now. From a radiopharmaceutical chemist's perspective, different precursors, radiolabeling approaches and purification methods are discussed as well as used automated radiosynthesizers, including cassette-based and microfluidic systems.In a GMP compliant radiosynthesis using original cassettes for FASTlab we produced [18F]FMISO in 49
%K Automated radiosynthesis (Other)
%K FASTlab (Other)
%K [18F]FMISO (Other)
%K [18F]fluoromisonidazole (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36897480
%2 pmc:PMC10006378
%R 10.1186/s41181-023-00190-7
%U https://inrepo02.dkfz.de/record/274209