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@ARTICLE{Kniess:274209,
      author       = {T. Kniess and J. Zessin and P. Mäding and M. Kuchar and O.
                      Kiss and K. Kopka$^*$},
      title        = {{S}ynthesis of [18{F}]{FMISO}, a hypoxia-specific imaging
                      probe for {PET}, an overview from a radiochemist's
                      perspective.},
      journal      = {EJNMMI radiopharmacy and chemistry},
      volume       = {8},
      number       = {1},
      issn         = {2365-421X},
      address      = {[Heidelberg]},
      publisher    = {SpringerOpen},
      reportid     = {DKFZ-2023-00495},
      pages        = {5},
      year         = {2023},
      abstract     = {[18F]fluoromisonidazole ([18F]FMISO,
                      1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a
                      commonly used radiotracer for imaging hypoxic conditions in
                      cells. Since hypoxia is prevalent in solid tumors,
                      [18F]FMISO is in clinical application for decades to explore
                      oxygen demand in cancer cells and the resulting impact on
                      radiotherapy and chemotherapy.Since the introduction of
                      [18F]FMISO as positron emission tomography imaging agent in
                      1986, a variety of radiosynthesis procedures for the
                      production of this hypoxia tracer has been developed. This
                      paper gives a brief overview on [18F]FMISO radiosyntheses
                      published so far from its introduction until now. From a
                      radiopharmaceutical chemist's perspective, different
                      precursors, radiolabeling approaches and purification
                      methods are discussed as well as used automated
                      radiosynthesizers, including cassette-based and microfluidic
                      systems.In a GMP compliant radiosynthesis using original
                      cassettes for FASTlab we produced [18F]FMISO in $49\%$
                      radiochemical yield within 48 min with radiochemical
                      purities > $99\%$ and molar activities > 500 GBq/µmol. In
                      addition, we report an easy and efficient radiosynthesis of
                      [18F]FMISO, based on in-house prepared FASTlab cassettes,
                      providing the radiotracer for research and preclinical
                      purposes in good radiochemical yields $(39\%),$ high
                      radiochemical purities (> $99\%)$ and high molar activity (>
                      500 GBq/µmol) in a well-priced option.},
      keywords     = {Automated radiosynthesis (Other) / FASTlab (Other) /
                      [18F]FMISO (Other) / [18F]fluoromisonidazole (Other)},
      cin          = {DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36897480},
      pmc          = {pmc:PMC10006378},
      doi          = {10.1186/s41181-023-00190-7},
      url          = {https://inrepo02.dkfz.de/record/274209},
}