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@ARTICLE{Wang:274213,
      author       = {Z. Wang and T. Wang and G. Wu and L. Zhu$^*$ and J. Zhang},
      title        = {{C}linical {S}ignificance and {T}umor {M}icroenvironment
                      {C}haracterization of a {N}ovel {I}mmune-{R}elated {G}ene
                      {S}ignature in {B}ladder {C}ancer.},
      journal      = {Journal of Clinical Medicine},
      volume       = {12},
      number       = {5},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00499},
      pages        = {1892},
      year         = {2023},
      abstract     = {Cancer immunotherapy plays a crucial role in bladder cancer
                      (BC) progression. Increasing evidence has elucidated the
                      clinicopathologic significance of the tumor microenvironment
                      (TME) in predicting outcomes and therapeutic efficacy. This
                      study sought to establish a comprehensive analysis of the
                      immune-gene signature combined with TME to assist in BC
                      prognosis. We selected sixteen immune-related genes (IRGs)
                      after a weighted gene co-expression network and survival
                      analysis. Enrichment analysis revealed that these IRGs were
                      actively involved in Mitophagy and Renin secretion pathways.
                      After multivariable COX analysis, the IRGPI comprising
                      NCAM1, CNTN1, PTGIS, ADRB3, and ANLN was established to
                      predict the overall survival of BC, which was validated in
                      both TCGA and GSE13507 cohorts. In addition, a TME gene
                      signature was developed for molecular and prognosis
                      subtyping with unsupervised clustering, followed by a
                      panoramic landscape characterization of BC. In summary, the
                      IRGPI model developed in our study provided a valuable tool
                      with an improved prognosis for BC.},
      keywords     = {biomarker (Other) / bladder cancer (Other) / immune-related
                      genes (Other) / prognosis (Other) / tumor microenvironment
                      (Other)},
      cin          = {A430},
      ddc          = {610},
      cid          = {I:(DE-He78)A430-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36902678},
      doi          = {10.3390/jcm12051892},
      url          = {https://inrepo02.dkfz.de/record/274213},
}