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@ARTICLE{Steinfass:274237,
      author       = {T. Steinfass$^*$ and J. Poelchen$^*$ and Q. Sun$^*$ and G.
                      Mastrogiulio$^*$ and D. Novak$^*$ and M. Vierthaler and S.
                      Pardo$^*$ and A. Federico$^*$ and L. Hüser$^*$ and T.
                      Hielscher$^*$ and R. Carretero$^*$ and R. Offringa$^*$ and
                      P. Altevogt$^*$ and V. Umansky$^*$ and J. Utikal$^*$},
      title        = {{S}ecretogranin {II} influences the assembly and function
                      of {MHC} class {I} in melanoma.},
      journal      = {Experimental hematology $\&$ oncology},
      volume       = {12},
      number       = {1},
      issn         = {2162-3619},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2023-00523},
      pages        = {29},
      year         = {2023},
      note         = {#EA:A370#LA:A370#},
      abstract     = {Melanoma is the deadliest form of skin cancer showing
                      rising incidence over the past years. New insights into the
                      mechanisms of melanoma progression contributed to the
                      development of novel treatment options, such as
                      immunotherapies. However, acquiring resistance to treatment
                      poses a big problem to therapy success. Therefore,
                      understanding the mechanisms underlying resistance could
                      improve therapy efficacy. Correlating expression levels in
                      tissue samples of primary melanoma and metastases revealed
                      that secretogranin 2 (SCG2) is highly expressed in advanced
                      melanoma patients with poor overall survival (OS) rates. By
                      conducting transcriptional analysis between
                      SCG2-overexpressing (OE) and control melanoma cells, we
                      detected a downregulation of components of the antigen
                      presenting machinery (APM), which is important for the
                      assembly of the MHC class I complex. Flow cytometry analysis
                      revealed a downregulation of surface MHC class I expression
                      on melanoma cells that showed resistance towards the
                      cytotoxic activity of melanoma-specific T cells. IFNγ
                      treatment partially reversed these effects. Based on our
                      findings, we suggest that SCG2 might stimulate mechanisms of
                      immune evasion and therefore be associated with resistance
                      to checkpoint blockade and adoptive immunotherapy.},
      subtyp        = {Letter},
      keywords     = {HLA (Other) / MHC class I (Other) / Melanoma (Other) /
                      Prognosis (Other) / SCG2 (Other)},
      cin          = {A370 / D220 / B062 / C060 / D200},
      ddc          = {610},
      cid          = {I:(DE-He78)A370-20160331 / I:(DE-He78)D220-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)D200-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36906639},
      pmc          = {pmc:PMC10007832},
      doi          = {DOI: 10.1186/s40164-023-00387-1},
      url          = {https://inrepo02.dkfz.de/record/274237},
}