% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ceranski:274241,
      author       = {A. K. Ceranski$^*$ and M. J. Carreño-Gonzalez$^*$ and A.
                      Ehlers$^*$ and M. Colombo$^*$ and F. Cidre-Aranaz$^*$ and T.
                      Grünewald$^*$},
      title        = {{H}ypoxia and {HIF}s in {E}wing sarcoma: new perspectives
                      on a multi-facetted relationship.},
      journal      = {Molecular cancer},
      volume       = {22},
      number       = {1},
      issn         = {1476-4598},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2023-00527},
      pages        = {49},
      year         = {2023},
      note         = {#EA:B410#LA:B410#},
      abstract     = {Hypoxia develops during the growth of solid tumors and
                      influences tumoral activity in multiple ways. Low oxygen
                      tension is also present in the bone microenvironment where
                      Ewing sarcoma (EwS) - a highly aggressive pediatric cancer -
                      mainly arises. Hypoxia inducible factor 1 subunit alpha
                      (HIF-1-a) is the principal molecular mediator of the hypoxic
                      response in cancer whereas EWSR1::FLI1 constitutes the
                      oncogenic driver of EwS. Interaction of the two proteins has
                      been shown in EwS. Although a growing body of studies
                      investigated hypoxia and HIFs in EwS, their precise role for
                      EwS pathophysiology is not clarified to date. This review
                      summarizes and structures recent findings demonstrating that
                      hypoxia and HIFs play a role in EwS at multiple levels. We
                      propose to view hypoxia and HIFs as independent protagonists
                      in the story of EwS and give a perspective on their
                      potential clinical relevance as prognostic markers and
                      therapeutic targets in EwS treatment.},
      subtyp        = {Review Article},
      keywords     = {ARNT (Other) / Ewing sarcoma (Other) / HIF-1-a (Other) /
                      HIF-1-b (Other) / hypoxia (Other)},
      cin          = {B410 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)B410-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36915100},
      doi          = {10.1186/s12943-023-01750-w},
      url          = {https://inrepo02.dkfz.de/record/274241},
}