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@ARTICLE{Renovanz:274242,
      author       = {M. Renovanz and S. C. Kurz and J. Rieger and B. Walter and
                      H. Becker and H. Hille and P. Bombach and D. Rieger and L.
                      Grosse and L. Häusser and M. Skardelly and D. J. Merk and
                      F. Paulsen and E. Hoffmann and C. Gani and M. Neumann and R.
                      Beschorner$^*$ and O. Rieß$^*$ and C. Roggia and C.
                      Schroeder and S. Ossowski and S. Armeanu-Ebinger and A.
                      Gschwind and S. Biskup and M. Schulze and F. Fend$^*$ and S.
                      Singer$^*$ and L. Zender$^*$ and C. Lengerke$^*$ and S. Y.
                      Brucker$^*$ and T. Engler$^*$ and A. Forschner$^*$ and A.
                      Stenzl$^*$ and O. Kohlbacher$^*$ and S. Nahnsen$^*$ and G.
                      Gabernet and S. Fillinger and B. Bender and U. Ernemann and
                      Ö. Öner and J. Beha and H. S. Malek and Y. Möller and K.
                      Ruhm and M. Tatagiba and J. Schittenhelm$^*$ and M.
                      Bitzer$^*$ and N. Malek$^*$ and D. Zips$^*$ and G.
                      Tabatabai$^*$},
      title        = {{C}linical outcome of biomarker-guided therapies in adult
                      patients with tumors of the nervous system.},
      journal      = {Neuro-oncology advances},
      volume       = {5},
      number       = {1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2023-00528},
      pages        = {1-14},
      year         = {2023},
      abstract     = {The clinical utility of molecular profiling and targeted
                      therapies for neuro-oncology patients outside of clinical
                      trials is not established. We aimed at investigating
                      feasibility and clinical utility of molecular profiling and
                      targeted therapy in adult patients with advanced tumors in
                      the nervous system within a prospective observational
                      study.molecular tumor board (MTB)@ZPM (NCT03503149) is a
                      prospective observational precision medicine study for
                      patients with advanced tumors. After inclusion of patients,
                      we performed comprehensive molecular profiling, formulated
                      ranked biomarker-guided therapy recommendations based on
                      consensus by the MTB, and collected prospective clinical
                      outcome data.Here, we present initial data of 661 adult
                      patients with tumors of the nervous system enrolled by
                      December 31, 2021. Of these, 408 patients were presented at
                      the MTB. Molecular-instructed therapy recommendations could
                      be made in 380/408 $(93.1\%)$ cases and were prioritized by
                      evidence levels. Therapies were initiated in 86/380
                      $(22.6\%)$ cases until data cutoff. We observed a
                      progression-free survival ratio >1.3 in $31.3\%$ of
                      patients.Our study supports the clinical utility of
                      biomarker-guided therapies for neuro-oncology patients and
                      indicates clinical benefit in a subset of patients. Our data
                      might inform future clinical trials, translational studies,
                      and even clinical care.},
      keywords     = {MTB@ZPM-001 (NCT03503149) (Other) / Molecular tumor board
                      (Other) / precision medicine (Other) / real-world data
                      (Other) / targeted therapy (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36915613},
      pmc          = {pmc:PMC10007909},
      doi          = {10.1093/noajnl/vdad012},
      url          = {https://inrepo02.dkfz.de/record/274242},
}