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@ARTICLE{Vangalis:274319,
      author       = {V. Vangalis and E. A. Markakis and M. Knop$^*$ and A. D.
                      Pietro and M. A. Typas and I. A. Papaioannou},
      title        = {{C}omponents of {TOR} and {MAP} kinase signaling control
                      chemotropism and pathogenicity in the fungal pathogen
                      {V}erticillium dahliae.},
      journal      = {Microbiological research},
      volume       = {271},
      issn         = {0944-5013},
      address      = {Jena},
      publisher    = {Urban $\&$ Fischer},
      reportid     = {DKFZ-2023-00533},
      pages        = {127361},
      year         = {2023},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Filamentous fungi can sense useful resources and hazards in
                      their environment and direct growth of their hyphae
                      accordingly. Chemotropism ensures access to nutrients,
                      contact with other individuals (e.g., for mating), and
                      interaction with hosts in the case of pathogens. Previous
                      studies have revealed a complex chemotropic sensing
                      landscape during host-pathogen interactions, but the
                      underlying molecular machinery remains poorly characterized.
                      Here we studied mechanisms controlling directed hyphal
                      growth of the important plant-pathogenic fungus Verticillium
                      dahliae towards different chemoattractants. We found that
                      the homologs of the Rag GTPase Gtr1 and the
                      GTPase-activating protein Tsc2, an activator and a repressor
                      of the TOR kinase respectively, play important roles in
                      hyphal chemotropism towards nutrients, plant-derived
                      signals, and heterologous α-pheromone of Fusarium
                      oxysporum. Furthermore, important roles of these regulators
                      were identified in fungal development and pathogenicity. We
                      also found that the mitogen-activated protein kinase (MAPK)
                      Fus3 is required for chemotropism towards nutrients, while
                      the G protein-coupled receptor (GPCR) Ste2 and the MAPK Slt2
                      control chemosensing of plant-derived signals and
                      α-pheromone. Our study establishes V. dahliae as a suitable
                      model system for the analysis of fungal chemotropism and
                      discovers new components of chemotropic signaling during
                      growth and host-pathogen interactions of V. dahliae.},
      keywords     = {Autophagy (Other) / Chemotropism (Other) / Environmental
                      sensing (Other) / Pathogenicity (Other) / Verticillium
                      dahliae (Other) / mTOR signaling pathway (Other)},
      cin          = {A260},
      ddc          = {570},
      cid          = {I:(DE-He78)A260-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36921400},
      doi          = {10.1016/j.micres.2023.127361},
      url          = {https://inrepo02.dkfz.de/record/274319},
}