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@ARTICLE{Brtsch:274322,
      author       = {S. M. Brütsch and E. Madzharova and S. Pantasis and T.
                      Wüstemann and S. Gurri and H. Steenbock and A. Gazdhar and
                      G. Kuhn and P. Angel$^*$ and S. Bellusci and J. Brinckmann
                      and U. Auf dem Keller and S. Werner and M. R. Bordoli},
      title        = {{M}esenchyme-derived vertebrate lonesome kinase controls
                      lung organogenesis by altering the matrisome.},
      journal      = {Cellular and molecular life sciences},
      volume       = {80},
      number       = {4},
      issn         = {1420-682X},
      address      = {Cham (ZG)},
      publisher    = {Springer International Publishing AG},
      reportid     = {DKFZ-2023-00536},
      pages        = {89},
      year         = {2023},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Vertebrate lonesome kinase (VLK) is the only known secreted
                      tyrosine kinase and responsible for the phosphorylation of a
                      broad range of secretory pathway-resident and extracellular
                      matrix proteins. However, its cell-type specific functions
                      in vivo are still largely unknown. Therefore, we generated
                      mice lacking the VLK gene (protein kinase domain containing,
                      cytoplasmic (Pkdcc)) in mesenchymal cells. Most of the
                      homozygous mice died shortly after birth, most likely as a
                      consequence of their lung abnormalities and consequent
                      respiratory failure. E18.5 embryonic lungs showed a
                      reduction of alveolar type II cells, smaller bronchi, and an
                      increased lung tissue density. Global mass
                      spectrometry-based quantitative proteomics identified 97
                      proteins with significantly and at least 1.5-fold
                      differential abundance between genotypes. Twenty-five of
                      these had been assigned to the extracellular region and 15
                      to the mouse matrisome. Specifically, fibromodulin and
                      matrilin-4, which are involved in extracellular matrix
                      organization, were significantly more abundant in lungs from
                      Pkdcc knockout embryos. These results support a role for
                      mesenchyme-derived VLK in lung development through
                      regulation of matrix dynamics and the resulting modulation
                      of alveolar epithelial cell differentiation.},
      keywords     = {Collagen (Other) / Lung organogenesis (Other) / Pkdcc
                      (Other) / Proteomics (Other) / Skull (Other)},
      cin          = {A100},
      ddc          = {610},
      cid          = {I:(DE-He78)A100-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36920550},
      doi          = {10.1007/s00018-023-04735-6},
      url          = {https://inrepo02.dkfz.de/record/274322},
}