%0 Journal Article
%A Bogumil, Henri
%A Sill, Martin
%A Schrimpf, Daniel
%A Ismer, Britta
%A Blume, Christina
%A Rahmanzade, Ramin
%A Hinz, Felix
%A Cherkezov, Asan
%A Banan, Rouzbeh
%A Friedel, Dennis
%A Reuss, David E
%A Selt, Florian
%A Ecker, Jonas
%A Milde, Till
%A Pajtler, Kristian W
%A Schittenhelm, Jens
%A Hench, Jürgen
%A Frank, Stephan
%A Boldt, Henning B
%A Kristensen, Bjarne Winther
%A Scheie, David
%A Melchior, Linea C
%A Olesen, Viola
%A Sehested, Astrid
%A Boué, Daniel R
%A Abdullaev, Zied
%A Satgunaseelan, Laveniya
%A Kurth, Ina
%A Seidlitz, Annekatrin
%A White, Christine L
%A Ng, Ho-Keung
%A Shi, Zhi-Feng
%A Haberler, Christine
%A Deckert, Martina
%A Timmer, Marco
%A Goldbrunner, Roland
%A Tauziède-Espariat, Arnault
%A Varlet, Pascale
%A Brandner, Sebastian
%A Alexandrescu, Sanda
%A Snuderl, Matija
%A Aldape, Kenneth
%A Korshunov, Andrey
%A Witt, Olaf
%A Herold-Mende, Christel
%A Unterberg, Andreas
%A Wick, Wolfgang
%A Pfister, Stefan M
%A von Deimling, Andreas
%A Jones, David T W
%A Sahm, Felix
%A Sievers, Philipp
%T Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
%J Acta neuropathologica
%V 145
%N 5
%@ 0001-6322
%C Heidelberg
%I Springer
%M DKFZ-2023-00558
%P 667-680
%D 2023
%Z #EA:B300#LA:B360#LA:B300#LA:B062# / 2023 May;145(5):667-680
%X Glioneuronal tumors are a heterogenous group of CNS neoplasms that can be challenging to accurately diagnose. Molecular methods are highly useful in classifying these tumors-distinguishing precise classes from their histological mimics and identifying previously unrecognized types of tumors. Using an unsupervised visualization approach of DNA methylation data, we identified a novel group of tumors (n = 20) that formed a cluster separate from all established CNS tumor types. Molecular analyses revealed ATRX alterations (in 16/16 cases by DNA sequencing and/or immunohistochemistry) as well as potentially targetable gene fusions involving receptor tyrosine-kinases (RTK; mostly NTRK1-3) in all of these tumors (16/16; 100
%K ATRX (Other)
%K DNA methylation (Other)
%K Gene fusion (Other)
%K Glioneuronal tumor (Other)
%K NTRK (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36933012
%R 10.1007/s00401-023-02558-0
%U https://inrepo02.dkfz.de/record/274356