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@ARTICLE{CastaedaCorzo:274360,
      author       = {G.-J. Castañeda-Corzo and L.-F. Infante-Rodríguez and
                      J.-C. Villamil-Poveda and J. Bustillo and A. Cid-Arregui$^*$
                      and D.-A. García-Robayo},
      title        = {{A}ssociation of {P}revotella intermedia with oropharyngeal
                      cancer: {A} patient-control study.},
      journal      = {Heliyon},
      volume       = {9},
      number       = {3},
      issn         = {2405-8440},
      address      = {London [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00562},
      pages        = {e14293},
      year         = {2023},
      abstract     = {To investigate the frequencies and bacterial load of three
                      species of periodontal bacteria in samples from
                      oropharyngeal cancer patients versus healthy
                      individuals.This is a case-control study based on biopsies
                      collected from tumor tissues obtained from patients with
                      oropharyngeal squamous cell carcinoma between 2016 and 2017
                      and shed oral mucosal epithelial cells that were collected
                      from controls using the Cepimax® brush, carrying out
                      several brushings towards the posterior third edge of the
                      tongue and the cheek. Porphyromonas gingivalis, Tannerella
                      forsythia and Prevotella intermedia detection and absolute
                      quantification was determined through q-PCR. Statistical
                      analysis included a U- test, X 2 , Fisher's exact test, odds
                      ratio (OR) and Conditional logistic regression analysis and
                      unconditional regression analysis (p < 0.05).A total of 48
                      donors older than 55 years old participated in this study.
                      The population was distributed into 24 patients (cases) and
                      24 controls. A robust association was established in cases
                      and controls with significance regarding Prevotella
                      intermedia (OR: 15.00) and Porphyromonas gingivalis
                      (OR:11.00). In the comparison between the amount of each
                      bacteria in the groups, P. intermedia showed a higher
                      bacterial load in oropharyngeal cancer patients (p = 0.04).
                      However, multivariate analysis adjusted to the presence of
                      different bacteria and the diverse confounding variables did
                      not reveal significant differences for oropharyngeal cancer
                      association.P. gingivalis and P. intermedia were detected
                      more frequently in the group of patients with cancer. The
                      bivariate analysis of the bacterial load evidenced
                      significant differences for Prevotella intermedia,
                      suggesting that it could be associated with oropharyngeal
                      cancer.},
      keywords     = {Dysbiosis (Other) / Microbiota (Other) / Oropharyngeal
                      cancer (Other) / Periodontal bacteria (Other)},
      cin          = {D122},
      ddc          = {000},
      cid          = {I:(DE-He78)D122-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36938439},
      pmc          = {pmc:PMC10018557},
      doi          = {10.1016/j.heliyon.2023.e14293},
      url          = {https://inrepo02.dkfz.de/record/274360},
}