%0 Journal Article
%A Bostel, Tilmann
%A Akbaba, Sati
%A Wollschläger, Daniel
%A Mayer, Arnulf
%A Nikolaidou, Eirini
%A Murnik, Markus
%A Kirste, Simon
%A Rühle, Alexander
%A Grosu, Anca-Ligia
%A Debus, Jürgen
%A Fottner, Christian
%A Moehler, Markus
%A Grimminger, Peter
%A Schmidberger, Heinz
%A Nicolay, Nils
%T Chemoradiotherapy in geriatric patients with squamous cell carcinoma of the esophagus: Multi-center analysis on the value of standard treatment in the elderly.
%J Frontiers in oncology
%V 13
%@ 2234-943X
%C Lausanne
%I Frontiers Media
%M DKFZ-2023-00566
%P 1063670
%D 2023
%Z #LA:E055#
%X To evaluate the tolerability and outcomes of chemoradiation in elderly patients with locally advanced esophageal squamous cell carcinoma (ESCC).This multi-center retrospective analysis included 161 patients with SCC of the esophagus with a median age of 73 years (range 65-89 years) treated with definitive or neoadjuvant (chemo)radiotherapy between 2010 and 2019 at 3 large comprehensive cancer centers in Germany. Locoregional control (LRC), progression-free survival (PFS), distant metastasis-free survival (DMFS), overall survival (OS), and treatment-associated toxicities were analyzed, and parameters determining patient outcomes and treatment tolerance were assessed.The delivery of radiotherapy without dose reduction was possible in 149 patients (93
%K chemoradiation (Other)
%K elderly patients (Other)
%K esophageal cancer (Other)
%K radiotherapy (Other)
%K squamous cell cancer (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36937445
%2 pmc:PMC10022427
%R 10.3389/fonc.2023.1063670
%U https://inrepo02.dkfz.de/record/274364