TY  - JOUR
AU  - Bostel, Tilmann
AU  - Akbaba, Sati
AU  - Wollschläger, Daniel
AU  - Mayer, Arnulf
AU  - Nikolaidou, Eirini
AU  - Murnik, Markus
AU  - Kirste, Simon
AU  - Rühle, Alexander
AU  - Grosu, Anca-Ligia
AU  - Debus, Jürgen
AU  - Fottner, Christian
AU  - Moehler, Markus
AU  - Grimminger, Peter
AU  - Schmidberger, Heinz
AU  - Nicolay, Nils
TI  - Chemoradiotherapy in geriatric patients with squamous cell carcinoma of the esophagus: Multi-center analysis on the value of standard treatment in the elderly.
JO  - Frontiers in oncology
VL  - 13
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-00566
SP  - 1063670
PY  - 2023
N1  - #LA:E055#
AB  - To evaluate the tolerability and outcomes of chemoradiation in elderly patients with locally advanced esophageal squamous cell carcinoma (ESCC).This multi-center retrospective analysis included 161 patients with SCC of the esophagus with a median age of 73 years (range 65-89 years) treated with definitive or neoadjuvant (chemo)radiotherapy between 2010 and 2019 at 3 large comprehensive cancer centers in Germany. Locoregional control (LRC), progression-free survival (PFS), distant metastasis-free survival (DMFS), overall survival (OS), and treatment-associated toxicities were analyzed, and parameters determining patient outcomes and treatment tolerance were assessed.The delivery of radiotherapy without dose reduction was possible in 149 patients (93
KW  - chemoradiation (Other)
KW  - elderly patients (Other)
KW  - esophageal cancer (Other)
KW  - radiotherapy (Other)
KW  - squamous cell cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36937445
C2  - pmc:PMC10022427
DO  - DOI:10.3389/fonc.2023.1063670
UR  - https://inrepo02.dkfz.de/record/274364
ER  -