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@ARTICLE{Chung:274375,
      author       = {C. Chung and B. M. Verheijen and Z. Navapanich and E. G.
                      McGann and S. Shemtov and G.-J. Lai and P. Arora and A.
                      Towheed and S. Haroon and A. Holczbauer and S. Chang and Z.
                      Manojlovic and S. Simpson and K. W. Thomas and C. Kaplan and
                      P. van Hasselt and H. T. M. Timmers$^*$ and D. Erie and L.
                      Chen and J.-F. Gout and M. Vermulst},
      title        = {{E}volutionary conservation of the fidelity of
                      transcription.},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2023-00575},
      pages        = {1547},
      year         = {2023},
      abstract     = {Accurate transcription is required for the faithful
                      expression of genetic information. However, relatively
                      little is known about the molecular mechanisms that control
                      the fidelity of transcription, or the conservation of these
                      mechanisms across the tree of life. To address these issues,
                      we measured the error rate of transcription in five
                      organisms of increasing complexity and found that the error
                      rate of RNA polymerase II ranges from 2.9 × 10-6 ± 1.9 ×
                      10-7/bp in yeast to 4.0 × 10-6 ± 5.2 × 10-7/bp in worms,
                      5.69 × 10-6 ± 8.2 × 10-7/bp in flies, 4.9 × 10-6 ± 3.6
                      × 10-7/bp in mouse cells and 4.7 × 10-6 ± 9.9 × 10-8/bp
                      in human cells. These error rates were modified by various
                      factors including aging, mutagen treatment and gene
                      modifications. For example, the deletion or modification of
                      several related genes increased the error rate substantially
                      in both yeast and human cells. This research highlights the
                      evolutionary conservation of factors that control the
                      fidelity of transcription. Additionally, these experiments
                      provide a reasonable estimate of the error rate of
                      transcription in human cells and identify disease alleles in
                      a subunit of RNA polymerase II that display error-prone
                      transcription. Finally, we provide evidence suggesting that
                      the error rate and spectrum of transcription co-evolved with
                      our genetic code.},
      cin          = {FR01},
      ddc          = {500},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36941254},
      doi          = {10.1038/s41467-023-36525-w},
      url          = {https://inrepo02.dkfz.de/record/274375},
}