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@ARTICLE{Tredup:274378,
      author       = {C. Tredup and B. Ndreshkjana and N. S. Schneider and A.
                      Tjaden and A. M. Kemas and S. Youhanna and V. M. Lauschke
                      and B.-T. Berger and A. Krämer and L. M. Berger and S.
                      Röhm and S. Knapp and H. Farin$^*$ and S. Müller},
      title        = {{D}eep {A}nnotation of {D}onated {C}hemical {P}robes
                      ({DCP}) in {O}rganotypic {H}uman {L}iver {C}ultures and
                      {P}atient-{D}erived {O}rganoids from {T}umor and {N}ormal
                      {C}olorectum.},
      journal      = {ACS chemical biology},
      volume       = {18},
      number       = {4},
      issn         = {1554-8929},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DKFZ-2023-00578},
      pages        = {822-836},
      year         = {2023},
      note         = {2023 Apr 21;18(4):822-836},
      abstract     = {Well-characterized small molecules are essential tools for
                      studying the biology and therapeutic relevance of a target
                      protein. However, many compounds reported in the literature
                      and routinely studied in biomedical research lack the
                      potency and selectivity required for mechanistic cellular
                      studies on the function of a given protein. Furthermore,
                      commercially available compounds often do not include useful
                      tools developed by industry as part of their research and
                      development efforts, as they frequently remain proprietary.
                      The freely available donated chemical probe (DCP) library,
                      fueled by generous donations of compounds from industry and
                      academia, enables easy access to a steadily growing
                      collection of these valuable and well-characterized tools.
                      Here, we provide a systematic description of the current DCP
                      library collection and their associated comprehensive
                      characterization data, including a variety of in vitro and
                      cellular assays. Of note, we characterized the set in
                      relevant human primary models by employing hepatotoxicity
                      screening in primary human liver spheroids and viability
                      screening in patient-derived colorectal cancer organoids and
                      matched normal-adjacent epithelium. Taken together, the DCP
                      library represents a well-annotated, openly available
                      collection of tool compounds for studying a wide range of
                      targets, including kinases, G-protein-coupled receptors, and
                      ion channels. As such, it represents a unique resource for
                      the biomedical research community.},
      cin          = {FM01},
      ddc          = {540},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36944371},
      doi          = {10.1021/acschembio.2c00877},
      url          = {https://inrepo02.dkfz.de/record/274378},
}