%0 Journal Article
%A Köbel, Martin
%A Kang, Eun-Young
%A Weir, Ashley
%A Rambau, Peter F
%A Lee, Cheng-Han
%A Nelson, Gregg S
%A Ghatage, Prafull
%A Meagher, Nicola S
%A Riggan, Marjorie J
%A Alsop, Jennifer
%A Anglesio, Michael S
%A Beckmann, Matthias W
%A Bisinotto, Christiani
%A Boisen, Michelle
%A Boros, Jessica
%A Brand, Alison H
%A Brooks-Wilson, Angela
%A Carney, Michael E
%A Coulson, Penny
%A Courtney-Brooks, Madeleine
%A Cushing-Haugen, Kara L
%A Cybulski, Cezary
%A Deen, Suha
%A El-Bahrawy, Mona A
%A Elishaev, Esther
%A Erber, Ramona
%A Fereday, Sian
%A Fischer, Anna
%A Gayther, Simon A
%A Barquin-Garcia, Arantzazu
%A Gentry-Maharaj, Aleksandra
%A Gilks, C Blake
%A Gronwald, Helena
%A Grube, Marcel
%A Harnett, Paul R
%A Harris, Holly R
%A Hartkopf, Andreas D
%A Hartmann, Arndt
%A Hein, Alexander
%A Hendley, Joy
%A Hernandez, Brenda Y
%A Huang, Yajue
%A Jakubowska, Anna
%A Jimenez-Linan, Mercedes
%A Jones, Michael E
%A Kennedy, Catherine J
%A Kluz, Tomasz
%A Koziak, Jennifer M
%A Lesnock, Jaime
%A Lester, Jenny
%A Lubiński, Jan
%A Longacre, Teri A
%A Lycke, Maria
%A Mateoiu, Constantina
%A McCauley, Bryan M
%A McGuire, Valerie
%A Ney, Britta
%A Olawaiye, Alexander
%A Orsulic, Sandra
%A Osorio, Ana
%A Paz-Ares, Luis
%A Ramón Y Cajal, Teresa
%A Rothstein, Joseph H
%A Ruebner, Matthias
%A Schoemaker, Minouk J
%A Shah, Mitul
%A Sharma, Raghwa
%A Sherman, Mark E
%A Shvetsov, Yurii B
%A Singh, Naveena
%A Steed, Helen
%A Storr, Sarah J
%A Talhouk, Aline
%A Traficante, Nadia
%A Wang, Chen
%A Whittemore, Alice S
%A Widschwendter, Martin
%A Wilkens, Lynne R
%A Winham, Stacey J
%A Benitez, Javier
%A Berchuck, Andrew
%A Bowtell, David D
%A Candido Dos Reis, Francisco J
%A Campbell, Ian
%A Cook, Linda S
%A DeFazio, Anna
%A Doherty, Jennifer A
%A Fasching, Peter A
%A Fortner, Renée T
%A García, María J
%A Goodman, Marc T
%A Goode, Ellen L
%A Gronwald, Jacek
%A Huntsman, David G
%A Karlan, Beth Y
%A Kelemen, Linda E
%A Kommoss, Stefan
%A Le, Nhu D
%A Martin, Stewart G
%A Menon, Usha
%A Modugno, Francesmary
%A Pharoah, Paul Dp
%A Schildkraut, Joellen M
%A Sieh, Weiva
%A Staebler, Annette
%A Sundfeldt, Karin
%A Swerdlow, Anthony J
%A Ramus, Susan J
%A Brenton, James D
%T p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study.
%J The journal of pathology: clinical research
%V 9
%N 3
%@ 2056-4538
%C Chichester
%I Wiley
%M DKFZ-2023-00586
%P 208-222
%D 2023
%Z 2023 May;9(3):208-222
%X Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC], and clear cell carcinoma [CCC]) using a large multi-institutional cohort from the Ovarian Tumor Tissue Analysis (OTTA) consortium. p53 expression was assessed on 6,678 cases represented on tissue microarrays from 25 participating OTTA study sites using a previously validated immunohistochemical (IHC) assay as a surrogate for the presence and functional effect of TP53 mutations. Three abnormal expression patterns (overexpression, complete absence, and cytoplasmic) and the normal (wild type) pattern were recorded. Survival analyses were performed by histotype. The frequency of abnormal p53 expression was 93.4
%K TP53 (Other)
%K clear cell (Other)
%K endometrioid (Other)
%K high-grade serous carcinoma (Other)
%K ovarian cancer (Other)
%K p53 (Other)
%K prognosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36948887
%R 10.1002/cjp2.311
%U https://inrepo02.dkfz.de/record/274419