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@ARTICLE{Kbel:274419,
      author       = {M. Köbel and E.-Y. Kang and A. Weir and P. F. Rambau and
                      C.-H. Lee and G. S. Nelson and P. Ghatage and N. S. Meagher
                      and M. J. Riggan and J. Alsop and M. S. Anglesio and M. W.
                      Beckmann and C. Bisinotto and M. Boisen and J. Boros and A.
                      H. Brand and A. Brooks-Wilson and M. E. Carney and P.
                      Coulson and M. Courtney-Brooks and K. L. Cushing-Haugen and
                      C. Cybulski and S. Deen and M. A. El-Bahrawy and E. Elishaev
                      and R. Erber and S. Fereday and A. Fischer and S. A. Gayther
                      and A. Barquin-Garcia and A. Gentry-Maharaj and C. B. Gilks
                      and H. Gronwald and M. Grube and P. R. Harnett and H. R.
                      Harris and A. D. Hartkopf and A. Hartmann and A. Hein and J.
                      Hendley and B. Y. Hernandez and Y. Huang and A. Jakubowska
                      and M. Jimenez-Linan and M. E. Jones and C. J. Kennedy and
                      T. Kluz and J. M. Koziak and J. Lesnock and J. Lester and J.
                      Lubiński and T. A. Longacre and M. Lycke and C. Mateoiu and
                      B. M. McCauley and V. McGuire and B. Ney and A. Olawaiye and
                      S. Orsulic and A. Osorio and L. Paz-Ares and T. Ramón Y
                      Cajal and J. H. Rothstein and M. Ruebner and M. J.
                      Schoemaker and M. Shah and R. Sharma and M. E. Sherman and
                      Y. B. Shvetsov and N. Singh and H. Steed and S. J. Storr and
                      A. Talhouk and N. Traficante and C. Wang and A. S.
                      Whittemore and M. Widschwendter and L. R. Wilkens and S. J.
                      Winham and J. Benitez and A. Berchuck and D. D. Bowtell and
                      F. J. Candido Dos Reis and I. Campbell and L. S. Cook and A.
                      DeFazio and J. A. Doherty and P. A. Fasching and R. T.
                      Fortner$^*$ and M. J. García and M. T. Goodman and E. L.
                      Goode and J. Gronwald and D. G. Huntsman and B. Y. Karlan
                      and L. E. Kelemen and S. Kommoss and N. D. Le and S. G.
                      Martin and U. Menon and F. Modugno and P. D. Pharoah and J.
                      M. Schildkraut and W. Sieh and A. Staebler and K. Sundfeldt
                      and A. J. Swerdlow and S. J. Ramus and J. D. Brenton},
      collaboration = {A. Group},
      title        = {p53 and ovarian carcinoma survival: an {O}varian {T}umor
                      {T}issue {A}nalysis consortium study.},
      journal      = {The journal of pathology: clinical research},
      volume       = {9},
      number       = {3},
      issn         = {2056-4538},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-00586},
      pages        = {208-222},
      year         = {2023},
      note         = {2023 May;9(3):208-222},
      abstract     = {Our objective was to test whether p53 expression status is
                      associated with survival for women diagnosed with the most
                      common ovarian carcinoma histotypes (high-grade serous
                      carcinoma [HGSC], endometrioid carcinoma [EC], and clear
                      cell carcinoma [CCC]) using a large multi-institutional
                      cohort from the Ovarian Tumor Tissue Analysis (OTTA)
                      consortium. p53 expression was assessed on 6,678 cases
                      represented on tissue microarrays from 25 participating OTTA
                      study sites using a previously validated immunohistochemical
                      (IHC) assay as a surrogate for the presence and functional
                      effect of TP53 mutations. Three abnormal expression patterns
                      (overexpression, complete absence, and cytoplasmic) and the
                      normal (wild type) pattern were recorded. Survival analyses
                      were performed by histotype. The frequency of abnormal p53
                      expression was $93.4\%$ (4,630/4,957) in HGSC compared to
                      $11.9\%$ (116/973) in EC and $11.5\%$ (86/748) in CCC. In
                      HGSC, there were no differences in overall survival across
                      the abnormal p53 expression patterns. However, in EC and
                      CCC, abnormal p53 expression was associated with an
                      increased risk of death for women diagnosed with EC in
                      multivariate analysis compared to normal p53 as the
                      reference (hazard ratio [HR] = 2.18, $95\%$ confidence
                      interval [CI] 1.36-3.47, p = 0.0011) and with CCC (HR =
                      1.57, $95\%$ CI 1.11-2.22, p = 0.012). Abnormal p53 was also
                      associated with shorter overall survival in The
                      International Federation of Gynecology and Obstetrics stage
                      I/II EC and CCC. Our study provides further evidence that
                      functional groups of TP53 mutations assessed by abnormal
                      surrogate p53 IHC patterns are not associated with survival
                      in HGSC. In contrast, we validate that abnormal p53 IHC is a
                      strong independent prognostic marker for EC and demonstrate
                      for the first time an independent prognostic association of
                      abnormal p53 IHC with overall survival in patients with
                      CCC.},
      keywords     = {TP53 (Other) / clear cell (Other) / endometrioid (Other) /
                      high-grade serous carcinoma (Other) / ovarian cancer (Other)
                      / p53 (Other) / prognosis (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36948887},
      doi          = {10.1002/cjp2.311},
      url          = {https://inrepo02.dkfz.de/record/274419},
}