TY  - JOUR
AU  - Tinhofer, Ingeborg
AU  - Staudte, Stephanie
AU  - George, Stephen
TI  - Liquid biopsy in head neck cancer: ready for clinical routine diagnostics?
JO  - Current opinion in oncology
VL  - 35
IS  - 3
SN  - 1040-8746
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DKFZ-2023-00613
SP  - 151-157
PY  - 2023
N1  - 2023 May 1;35(3):151-157
AB  - The bodily fluids of patients with solid cancers representing a minimally-invasive source of clinically exploitable biomarkers have attracted an increasing amount of attention in recent years. In patients with head and neck squamous cell carcinoma (HNSCC), cell-free tumour DNA (ctDNA) belongs to the most promising liquid biomarkers for monitoring disease burden and identifying patients at high risk of recurrence. In this review, we highlight recent studies, evaluating the analytical validity and clinical utility of ctDNA as a dynamic biomarker in HNSCC, especially as it relates to risk stratification and contrasting human papilloma virus (HPV+ and HPV-) and carcinomas.The clinical potential of minimal residual disease monitoring through viral ctDNA in identifying HPV+ oropharyngeal carcinoma patients at higher risk of recurrence has recently been demonstrated. Furthermore, accumulating evidence supports a potential diagnostic value of ctDNA dynamics in HPV-negative HNSCC. Altogether, recent data suggest that ctDNA analysis may be a valuable tool in guiding (de)escalation of surgical interventions as well as adaptation in radiotherapy dosage, both in the definitive and adjuvant settings.Rigorous clinical trials with patient-relevant endpoints are critical in order to demonstrate that treatment decisions based on ctDNA dynamics result in better outcomes in HNSCC.
LB  - PUB:(DE-HGF)16
C6  - pmid:36966499
DO  - DOI:10.1097/CCO.0000000000000935
UR  - https://inrepo02.dkfz.de/record/274468
ER  -