TY  - JOUR
AU  - Mittelstadt, Suzana
AU  - Kelemen, Olga
AU  - Admard, Jakob
AU  - Gschwind, Axel
AU  - Koch, André
AU  - Wörz, Sarah
AU  - Oberlechner, Ernst
AU  - Engler, Tobias
AU  - Bonzheim, Irina
AU  - Staebler, Annette
AU  - Weidner, Nicola
AU  - Stubenrauch, Frank
AU  - Iftner, Thomas
AU  - Riess, Olaf
AU  - Schroeder, Christopher
AU  - Kommoss, Stefan
AU  - Ossowski, Stephan
TI  - Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse.
JO  - British journal of cancer
VL  - 128
IS  - 11
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2023-00617
SP  - 2097-2103
PY  - 2023
N1  - 2023 Jun;128(11):2097-2103
AB  - HPV-related cervical cancer (CC) is the fourth most frequent cancer in women worldwide. Cell-free tumour DNA is a potent biomarker to detect treatment response, residual disease, and relapse. We investigated the potential use of cell-free circulating HPV-DNA (cfHPV-DNA) in plasma of patients with CC.cfHPV-DNA levels were measured using a highly sensitive next-generation sequencing-based approach targeting a panel of 13 high-risk HPV types.Sequencing was performed in 69 blood samples collected from 35 patients, of which 26 were treatment-naive when the first liquid biopsy sample was retrieved. cfHPV-DNA was successfully detected in 22/26 (85
LB  - PUB:(DE-HGF)16
C6  - pmid:36973448
DO  - DOI:10.1038/s41416-023-02233-x
UR  - https://inrepo02.dkfz.de/record/274472
ER  -