%0 Journal Article
%A Kramer, Carsten Sven
%A Kanagasundaram, Thines
%A Matthias, Jessica
%A Kopka, Klaus
%T Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes
%J Pharmaceuticals
%V 16
%N 3
%@ 1424-8247
%C Basel
%I MDPI
%M DKFZ-2023-00641
%P 401
%D 2023
%Z #EA:E030#LA:E030#
%X Tracers for bimodal optical imaging and positron emission tomography unite multipleadvantages in a single molecule. Their tumor-specific uptake can be visualized after their PETactivation by radiofluorination via PET/CT or PET/MRI allowing for staging or therapy planning,while their non-radioactive moiety additionally facilitates the visualization of malignant tissueduring intraoperative fluorescence-guided surgery or in histological assessments. The silicon-bridgedxanthene core offers the opportunity for radiofluorination with SiFA isotope exchange to obtaina small-molecule, PET-activatable NIR dye that can be linked to different target vectors. Herein,we demonstrate for the first time the PET-activation of a fluorinated silicon pyronine, belongingto a class of low-molecular-weight fluorescence dyes with a large Stokes shift (up to 129 nm) andsolvent-dependent NIR dye properties, with a successful radiochemical conversion of 70
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36986500
%R 10.3390/ph16030401
%U https://inrepo02.dkfz.de/record/274564