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@ARTICLE{Lckerath:274566,
      author       = {K. Lückerath$^*$ and M. Trajkovic-Arsic$^*$ and C. E.
                      Mona},
      title        = {{F}ibroblast {A}ctivation {P}rotein {I}nhibitor
                      {T}heranostics: {P}reclinical {C}ombination {T}reatment.},
      journal      = {PET clinics},
      volume       = {18},
      number       = {3},
      issn         = {1556-8598},
      address      = {Orlando, Fla. [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00643},
      pages        = {409-418},
      year         = {2023},
      note         = {2023 Jul;18(3):409-418},
      abstract     = {Fibroblast activation protein (FAP)-radioligand therapy
                      might be effective in some patients without being curative.
                      FAP-radioligands deliver ionizing radiation directly to FAP+
                      cancer-associated fibroblasts and, in some cancers, to FAP+
                      tumor cells; in addition, they indirectly irradiate FAP-
                      cells in tumor tissue via cross-fire and bystander effects.
                      Here, we discuss the potential to improve FAP-radioligand
                      therapy through interfering with DNA damage repair,
                      immunotherapy, and co-targeting cancer-associated
                      fibroblasts. As the molecular and cellular effects of
                      FAP-radioligands on the tumor and its microenvironment have
                      not been investigated yet, we call for future research to
                      close this gap in knowledge, which prevents the development
                      of more effective FAP-radioligand therapies.},
      subtyp        = {Review Article},
      keywords     = {Combination therapy (Other) / Fibroblast activation protein
                      (Other) / Radioligand (Other) / Theranostics (Other) / Tumor
                      microenvironment (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36990945},
      doi          = {10.1016/j.cpet.2023.02.006},
      url          = {https://inrepo02.dkfz.de/record/274566},
}