%0 Journal Article
%A Bonet, Catalina
%A Crous-Bou, Marta
%A Tsilidis, Konstantinos K
%A Gunter, Marc J
%A Kaaks, Rudolf
%A Schulze, Matthias B
%A Fortner, Renée T
%A Antoniussen, Christian S
%A Dahm, Christina C
%A Mellemkjær, Lene
%A Tjønneland, Anne
%A Amiano, Pilar
%A Ardanaz, Eva
%A Colorado-Yohar, Sandra M
%A Rodriguez-Barranco, Miguel
%A Tin Tin, Sandar
%A Agnoli, Claudia
%A Masala, Giovanna
%A Panico, Salvatore
%A Sacerdote, Carlotta
%A May, Anne M
%A Borch, Kristin Benjaminsen
%A Rylander, Charlotta
%A Skeie, Guri
%A Christakoudi, Sofia
%A Aune, Dagfinn
%A Weiderpass, Elisabete
%A Dossus, Laure
%A Riboli, Elio
%A Agudo, Antonio
%T The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study.
%J European journal of epidemiology
%V 38
%N 5
%@ 0393-2990
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2023-00648
%P 545-557
%D 2023
%Z 2023 May;38(5):545-557
%X Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study included 13,624 BC survivors from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with a mean follow-up of 8.6 years after diagnosis. Anthropometric data were obtained at recruitment for all cases and at a second assessment during follow-up for a subsample. We measured general obesity using the body mass index (BMI), whereas waist circumference and A Body Shape Index were used as measures of abdominal obesity. The annual weight change was calculated for cases with two weight assessments. The association with overall mortality and BC-specific mortality were based on a multivariable Cox and Fine and Gray models, respectively. We performed Mendelian randomization (MR) analysis to investigate the potential causal association. Five-unit higher BMI prediagnosis was associated with a 10
%K Body fatness (Other)
%K Breast cancer survivors (Other)
%K Breast cancer-specific mortality (Other)
%K Mortality (Other)
%K Prospective study (Other)
%K Weight change (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36988840
%R 10.1007/s10654-023-00979-5
%U https://inrepo02.dkfz.de/record/274571