TY  - JOUR
AU  - Bonet, Catalina
AU  - Crous-Bou, Marta
AU  - Tsilidis, Konstantinos K
AU  - Gunter, Marc J
AU  - Kaaks, Rudolf
AU  - Schulze, Matthias B
AU  - Fortner, Renée T
AU  - Antoniussen, Christian S
AU  - Dahm, Christina C
AU  - Mellemkjær, Lene
AU  - Tjønneland, Anne
AU  - Amiano, Pilar
AU  - Ardanaz, Eva
AU  - Colorado-Yohar, Sandra M
AU  - Rodriguez-Barranco, Miguel
AU  - Tin Tin, Sandar
AU  - Agnoli, Claudia
AU  - Masala, Giovanna
AU  - Panico, Salvatore
AU  - Sacerdote, Carlotta
AU  - May, Anne M
AU  - Borch, Kristin Benjaminsen
AU  - Rylander, Charlotta
AU  - Skeie, Guri
AU  - Christakoudi, Sofia
AU  - Aune, Dagfinn
AU  - Weiderpass, Elisabete
AU  - Dossus, Laure
AU  - Riboli, Elio
AU  - Agudo, Antonio
TI  - The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study.
JO  - European journal of epidemiology
VL  - 38
IS  - 5
SN  - 0393-2990
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2023-00648
SP  - 545-557
PY  - 2023
N1  - 2023 May;38(5):545-557
AB  - Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study included 13,624 BC survivors from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with a mean follow-up of 8.6 years after diagnosis. Anthropometric data were obtained at recruitment for all cases and at a second assessment during follow-up for a subsample. We measured general obesity using the body mass index (BMI), whereas waist circumference and A Body Shape Index were used as measures of abdominal obesity. The annual weight change was calculated for cases with two weight assessments. The association with overall mortality and BC-specific mortality were based on a multivariable Cox and Fine and Gray models, respectively. We performed Mendelian randomization (MR) analysis to investigate the potential causal association. Five-unit higher BMI prediagnosis was associated with a 10
KW  - Body fatness (Other)
KW  - Breast cancer survivors (Other)
KW  - Breast cancer-specific mortality (Other)
KW  - Mortality (Other)
KW  - Prospective study (Other)
KW  - Weight change (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36988840
DO  - DOI:10.1007/s10654-023-00979-5
UR  - https://inrepo02.dkfz.de/record/274571
ER  -