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000274574 1001_ $$0P:(DE-He78)bac8c2c56238485ecf0475ff14438430$$aAhmed, Azaz$$b0$$eFirst author$$udkfz
000274574 245__ $$aSex Differences in the Systemic and Local Immune Response of Pancreatic Cancer Patients.
000274574 260__ $$aBasel$$bMDPI$$c2023
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000274574 520__ $$aMounting evidence suggests that sex plays a critical role in various aspects of cancer such as immune responses. However, a male bias exists in human and non-human studies including immunotherapy trials. The role of sex on immune responses in pancreatic ductal adenocarcinoma (PDA) is unclear.Here, tumor tissues (tumor and stroma separately) and corresponding blood samples from patients with PDA (n = 52) were systematically analyzed by immunohistochemistry and multiplex cytokine measurements and compared by sex.Females showed a stronger systemic immune response with higher levels of CXCL9, IL1B, IL6, IL10 and IL13. Additionally, more peripheral white blood cells were detected in females. In the microenvironment, males showed higher tumoral levels of CXCL12. No differences were detected in the stroma. Females showed a tendency towards an anti-tumoral immune cell profile. CXCL12 blockade indicated a differential microenvironmental effect by sex in an independent immunotherapy trial cohort of patients with PDA (one female, five males). The overall survival did not differ by sex in our cohort.Systemic and local immune responses differ between sexes in PDA. Accordingly, sex-dependent differences need to be considered in human studies and for specific immunological interventions before clinical translation.
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000274574 650_7 $$2Other$$aCXCL12
000274574 650_7 $$2Other$$apancreatic cancer
000274574 650_7 $$2Other$$apancreatic ductal adenocarcinoma
000274574 650_7 $$2Other$$asex difference
000274574 650_7 $$2Other$$atumor immunology
000274574 7001_ $$aKöhler, Sophia$$b1
000274574 7001_ $$00000-0003-4123-261X$$aKlotz, Rosa$$b2
000274574 7001_ $$aGiese, Nathalia$$b3
000274574 7001_ $$aHackert, Thilo$$b4
000274574 7001_ $$aSpringfeld, Christoph$$b5
000274574 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b6$$udkfz
000274574 7001_ $$0P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aHalama, Niels$$b7$$eLast author$$udkfz
000274574 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers15061815$$gVol. 15, no. 6, p. 1815 -$$n6$$p1815$$tCancers$$v15$$x2072-6694$$y2023
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