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@ARTICLE{Gretser:274580,
      author       = {S. Gretser and K. Weber$^*$ and Y. Braun and P. N. Harter
                      and U. Rolle and J. McNally and E. Gradhand},
      title        = {{T}issue {S}hrinkage of {R}esected {S}pecimens in
                      {H}irschsprung's {D}isease: {W}hy {P}ediatric {S}urgeons
                      {T}hink the {B}owel {S}pecimen was {L}onger {T}han
                      {I}ndicated in the {P}athology {R}eport.},
      journal      = {Pediatric and developmental pathology},
      volume       = {26},
      number       = {3},
      issn         = {1093-5266},
      address      = {Thousand Oaks, CA},
      publisher    = {Sage Publishing},
      reportid     = {DKFZ-2023-00657},
      pages        = {287-291},
      year         = {2023},
      note         = {2023 May-Jun;26(3):287-291},
      abstract     = {Hirschsprung disease (HD) is an aganglionosis of variable
                      length starting at the rectosigmoid colon with surgery as
                      sole therapeutic option. The length of the resected bowel
                      segment is a crucial information for the treating surgeons
                      and influences the prognosis of the patient. It is often
                      artificially altered due to post operative tissue shrinkage.
                      The objective of this study is to quantify the extent tissue
                      shrinkage of HD specimens.Colorectal HD specimens were
                      measured at the time of surgery and at the time of cut-up,
                      either fresh or after formalin fixation and statistically
                      analyzed.Sixteen colorectal specimens were included.
                      Following formalin fixation the specimen length decreased by
                      $22.7\%$ (P < .001). Without formalin fixation the specimens
                      shrank by an average of $24.9\%$ (P = .05). There was no
                      significant difference in the extent of tissue shrinkage
                      with or without formalin fixation (P = .76).This study
                      showed that there is significant tissue shrinkage in HD
                      specimens. The 2 different cohorts revealed that tissue
                      shrinkage is mostly caused by tissue retraction/alteration
                      after organ removal but also to a lesser extent by fixation
                      with formalin. Surgeons and (neuro-)pathologists should be
                      aware of the sizeable shrinking artifact to avoid
                      unnecessary confusion.},
      keywords     = {GI (Other) / Hirschsprung (Other) / PediPath (Other) / Surg
                      Path (Other) / neuropathology (Other) / pediatric (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36994845},
      doi          = {10.1177/10935266231162684},
      url          = {https://inrepo02.dkfz.de/record/274580},
}