TY  - JOUR
AU  - Acker, Gueliz
AU  - Nachbar, Marcel
AU  - Soffried, Nina
AU  - Bodnar, Bohdan
AU  - Janas, Anastasia
AU  - Krantchev, Kiril
AU  - Kalinauskaite, Goda
AU  - Kluge, Anne
AU  - Shultz, David
AU  - Conti, Alfredo
AU  - Kaul, David
AU  - Zips, Daniel
AU  - Vajkoczy, Peter
AU  - Senger, Carolin
TI  - What if: A retrospective reconstruction of resection cavity stereotactic radiosurgery to mimic neoadjuvant stereotactic radiosurgery.
JO  - Frontiers in oncology
VL  - 13
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-00681
SP  - 1056330
PY  - 2023
AB  - Neoadjuvant stereotactic radiosurgery (NaSRS) of brain metastases has gained importance, but it is not routinely performed. While awaiting the results of prospective studies, we aimed to analyze the changes in the volume of brain metastases irradiated pre- and postoperatively and the resulting dosimetric effects on normal brain tissue (NBT).We identified patients treated with SRS at our institution to compare hypothetical preoperative gross tumor and planning target volumes (pre-GTV and pre-PTV) with original postoperative resection cavity volumes (post-GTV and post-PTV) as well as with a standardized-hypothetical PTV with 2.0 mm margin. We used Pearson correlation to assess the association between the GTV and PTV changes with the pre-GTV. A multiple linear regression analysis was established to predict the GTV change. Hypothetical planning for the selected cases was created to assess the volume effect on the NBT exposure. We performed a literature review on NaSRS and searched for ongoing prospective trials.We included 30 patients in the analysis. The pre-/post-GTV and pre-/post-PTV did not differ significantly. We observed a negative correlation between pre-GTV and GTV-change, which was also a predictor of volume change in the regression analysis, in terms of a larger volume change for a smaller pre-GTV. In total, 62.5
KW  - CyberKnife® (Other)
KW  - brain metastases (BM) (Other)
KW  - neoadjuvant (Other)
KW  - preoperative (Other)
KW  - stereotactic radiosurgery (SRS) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37007157
C2  - pmc:PMC10062706
DO  - DOI:10.3389/fonc.2023.1056330
UR  - https://inrepo02.dkfz.de/record/275223
ER  -