TY  - JOUR
AU  - Striefler, Jana K
AU  - Binder, Phung T
AU  - Brandes, Franziska
AU  - Rau, Daniel
AU  - Wittenberg, Silvan
AU  - Kaul, David
AU  - Roohani, Siyer
AU  - Jarosch, Armin
AU  - Schäfer, Frederik M
AU  - Öllinger, Robert
AU  - Märdian, Sven
AU  - Bullinger, Lars
AU  - Eckardt, Kai-Uwe
AU  - Kruse, Jan
AU  - Flörcken, Anne
TI  - Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters.
JO  - Cancer management and research
VL  - 15
SN  - 1179-1322
CY  - Albany, Auckland
PB  - Dove Medical Press
M1  - DKFZ-2023-00682
SP  - 321 - 334
PY  - 2023
AB  - Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on the characteristics and clinical outcome of sarcoma patients admitted to intensive care units (ICU) are sparse.We performed a retrospective analysis of sarcoma patients admitted to the ICU from 2005 to 2022. Patients ≥18 years with histologically proven sarcoma were included in our study.Sixty-six patients were eligible for analysis. The following characteristics had significant impact on overall survival: sex (p=0.046), tumour localization (p=0.02), therapeutic intention (p=0.02), line of chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA score (p=0.02).Our study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients. For overall survival, common clinical characteristics are also of significant value. Further investigation is needed to optimize ICU treatment of sarcoma patients.
KW  - ICU-specific survival (Other)
KW  - SAPS II (Other)
KW  - SOFA (Other)
KW  - intensive care unit (Other)
KW  - sepsis and performance scores (Other)
KW  - soft tissue sarcoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37009630
C2  - pmc:PMC10065007
DO  - DOI:10.2147/CMAR.S400430
UR  - https://inrepo02.dkfz.de/record/275224
ER  -