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@ARTICLE{Striefler:275224,
      author       = {J. K. Striefler and P. T. Binder and F. Brandes and D. Rau
                      and S. Wittenberg and D. Kaul and S. Roohani and A. Jarosch
                      and F. M. Schäfer and R. Öllinger and S. Märdian and L.
                      Bullinger$^*$ and K.-U. Eckardt and J. Kruse and A.
                      Flörcken$^*$},
      title        = {{S}arcoma {P}atients {A}dmitted to the {I}ntensive {C}are
                      {U}nit ({ICU}): {P}redictive {R}elevance of {C}ommon
                      {S}epsis and {P}erformance {P}arameters.},
      journal      = {Cancer management and research},
      volume       = {15},
      issn         = {1179-1322},
      address      = {Albany, Auckland},
      publisher    = {Dove Medical Press},
      reportid     = {DKFZ-2023-00682},
      pages        = {321 - 334},
      year         = {2023},
      abstract     = {Prognosis of sarcoma patients is improving, with a better
                      understanding of sarcomagenesis revealing novel therapeutic
                      targets. However, aggressive chemotherapy remains an
                      essential part of treatment, bearing the risk of severe side
                      effects that require intensive medical treatment. Available
                      data on the characteristics and clinical outcome of sarcoma
                      patients admitted to intensive care units (ICU) are
                      sparse.We performed a retrospective analysis of sarcoma
                      patients admitted to the ICU from 2005 to 2022. Patients
                      ≥18 years with histologically proven sarcoma were included
                      in our study.Sixty-six patients were eligible for analysis.
                      The following characteristics had significant impact on
                      overall survival: sex (p=0.046), tumour localization
                      (p=0.02), therapeutic intention (p=0.02), line of
                      chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA
                      score (p=0.02).Our study confirms the predictive relevance
                      of established sepsis and performance scores in sarcoma
                      patients. For overall survival, common clinical
                      characteristics are also of significant value. Further
                      investigation is needed to optimize ICU treatment of sarcoma
                      patients.},
      keywords     = {ICU-specific survival (Other) / SAPS II (Other) / SOFA
                      (Other) / intensive care unit (Other) / sepsis and
                      performance scores (Other) / soft tissue sarcoma (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37009630},
      pmc          = {pmc:PMC10065007},
      doi          = {10.2147/CMAR.S400430},
      url          = {https://inrepo02.dkfz.de/record/275224},
}