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000275263 1001_ $$aLiu, Yanling$$b0
000275263 245__ $$aEtiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.
000275263 260__ $$a[London]$$bNature Publishing Group UK$$c2023
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000275263 520__ $$aOncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, predict outcome, persist through treatment, and can be ideal therapeutic targets. However, mechanistic understanding of the etiology of oncogenic fusions remains elusive. Here we report a comprehensive detection of 272 oncogenic fusion gene pairs by using tumor transcriptome sequencing data from 5190 childhood cancer patients. We identify diverse factors, including translation frame, protein domain, splicing, and gene length, that shape the formation of oncogenic fusions. Our mathematical modeling reveals a strong link between differential selection pressure and clinical outcome in CBFB-MYH11. We discover 4 oncogenic fusions, including RUNX1-RUNX1T1, TCF3-PBX1, CBFA2T3-GLIS2, and KMT2A-AFDN, with promoter-hijacking-like features that may offer alternative strategies for therapeutic targeting. We uncover extensive alternative splicing in oncogenic fusions including KMT2A-MLLT3, KMT2A-MLLT10, C11orf95-RELA, NUP98-NSD1, KMT2A-AFDN and ETV6-RUNX1. We discover neo splice sites in 18 oncogenic fusion gene pairs and demonstrate that such splice sites confer therapeutic vulnerability for etiology-based genome editing. Our study reveals general principles on the etiology of oncogenic fusions in childhood cancer and suggests profound clinical implications including etiology-based risk stratification and genome-editing-based therapeutics.
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000275263 7001_ $$aKlein, Jonathon$$b1
000275263 7001_ $$aBajpai, Richa$$b2
000275263 7001_ $$aDong, Li$$b3
000275263 7001_ $$aTran, Quang$$b4
000275263 7001_ $$00000-0003-0044-0076$$aKolekar, Pandurang$$b5
000275263 7001_ $$aSmith, Jenny L$$b6
000275263 7001_ $$00000-0002-3702-7923$$aRies, Rhonda E$$b7
000275263 7001_ $$00000-0001-6996-0833$$aHuang, Benjamin J$$b8
000275263 7001_ $$aWang, Yi-Cheng$$b9
000275263 7001_ $$aAlonzo, Todd A$$b10
000275263 7001_ $$00000-0001-9921-0603$$aTian, Liqing$$b11
000275263 7001_ $$00000-0003-2024-9498$$aMulder, Heather L$$b12
000275263 7001_ $$00000-0002-9316-1924$$aShaw, Timothy I$$b13
000275263 7001_ $$aMa, Jing$$b14
000275263 7001_ $$aWalsh, Michael P$$b15
000275263 7001_ $$aSong, Guangchun$$b16
000275263 7001_ $$00000-0002-1000-6698$$aWestover, Tamara$$b17
000275263 7001_ $$0P:(DE-He78)50c2928009c788a6a5f3a0708dfb6df5$$aAutry, Robert J$$b18$$udkfz
000275263 7001_ $$aGout, Alexander M$$b19
000275263 7001_ $$aWheeler, David A$$b20
000275263 7001_ $$00000-0003-0661-2684$$aWan, Shibiao$$b21
000275263 7001_ $$00000-0002-1678-5864$$aWu, Gang$$b22
000275263 7001_ $$00000-0002-0770-9659$$aYang, Jun J$$b23
000275263 7001_ $$00000-0002-9333-5322$$aEvans, William E$$b24
000275263 7001_ $$aLoh, Mignon$$b25
000275263 7001_ $$00000-0003-4503-6608$$aEaston, John$$b26
000275263 7001_ $$00000-0003-3350-9682$$aZhang, Jinghui$$b27
000275263 7001_ $$00000-0003-2961-6960$$aKlco, Jeffery M$$b28
000275263 7001_ $$aMeshinchi, Soheil$$b29
000275263 7001_ $$00000-0002-8653-1069$$aBrown, Patrick A$$b30
000275263 7001_ $$00000-0002-3793-585X$$aPruett-Miller, Shondra M$$b31
000275263 7001_ $$00000-0002-6233-2145$$aMa, Xiaotu$$b32
000275263 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-023-37438-4$$gVol. 14, no. 1, p. 1739$$n1$$p1739$$tNature Communications$$v14$$x2041-1723$$y2023
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