TY  - JOUR
AU  - Kharazmi, Elhamalsadat
AU  - Scherer, Dominique
AU  - Boekstegers, Felix
AU  - Liang, Qunfeng
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Fallah, Mahdi
AU  - Bermejo, Justo Lorenzo
TI  - Gallstones, cholecystectomy and kidney cancer: observational and Mendelian randomisation results based on large cohorts.
JO  - Gastroenterology
VL  - 165
IS  - 1
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2023-00748
SP  - 218-227.e8
PY  - 2023
N1  - #LA:C120# / 165(1), pp. 218-227.e8
AB  - Gallstones (cholelithiasis) constitute a major health burden with high costs related to surgical removal of the gallbladder (cholecystectomy), generally indicated for symptomatic gallstones. The association between gallstones, cholecystectomy and kidney cancer is controversial. We comprehensively investigated this association, considering age at cholecystectomy and time from cholecystectomy to kidney cancer diagnosis, and assessing the causal effect of gallstones on kidney cancer risk by Mendelian randomisation (MR).We compared the risk of kidney cancer in cholecystectomised and non-cholecystectomised individuals (16.6 million in total) from the Swedish nationwide cancer, census, patient and death registries using hazard ratios (HRs). For two-sample and multivariable MR, we used summary statistics based on 408,567 UK Biobank participants.During a median follow-up of 13 years, 2,627 of 627,870 cholecystectomised Swedish patients developed kidney cancer (HR=1.17, 95
KW  - cancer prevention (Other)
KW  - causal inference (Other)
KW  - large nation-wide cohorts (Other)
KW  - risk prediction (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37054756
DO  - DOI:10.1053/j.gastro.2023.03.227
UR  - https://inrepo02.dkfz.de/record/275425
ER  -