TY  - JOUR
AU  - Heinz, Amadeus T
AU  - Ebinger, Martin
AU  - Schönstein, Anton
AU  - Fuchs, Jörg
AU  - Timmermann, Beate
AU  - Seitz, Guido
AU  - Vokuhl, Christian
AU  - Münter, Marc W
AU  - Pajtler, Kristian
AU  - Stegmaier, Sabine
AU  - von Kalle, Thekla
AU  - Kratz, Christian P
AU  - Rößler, Jochen
AU  - Ljungman, Gustaf
AU  - Klingebiel, Thomas
AU  - Koscielniak, Ewa
AU  - Sparber-Sauer, Monika
TI  - Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR).
JO  - Pediatric blood & cancer
VL  - 70
IS  - 7
SN  - 1545-5009
CY  - New York, NY
PB  - Wiley
M1  - DKFZ-2023-00771
SP  - e30363
PY  - 2023
N1  - 2023 Jul;70(7):e30363
AB  - Outcome of relapsed disease of localized rhabdomyosarcoma remains poor. An individual treatment approach considering the initial systemic treatment and risk group was included in the Cooperative Weichteilsarkom Studiengruppe (CWS) Guidance.Second-line chemotherapy (sCHT) ACCTTIVE based on anthracyclines (adriamycin, carboplatin, cyclophosphamide, topotecan, vincristine, etoposide) was recommended for patients with initial low- (LR), standard- (SR), and high-risk (HR) group after initial treatment without anthracyclines. TECC (topotecan, etoposide, carboplatin, cyclophosphamide) was recommended after initial anthracycline-based regimen in the very high-risk (VHR) group. Data of patients with relapse (n = 68) registered in the European Soft Tissue Sarcoma Registry SoTiSaR (2009-2018) were retrospectively analyzed.Patients of initial LR (n = 2), SR (n = 16), HR (n = 41), and VHR (n = 9) group relapsed. sCHT consisted of ACCTTIVE (n = 36), TECC (n = 12), or other (n = 15). Resection was performed in 40/68 (59
KW  - Soft Tissue Sarcoma Registry (SoTiSaR) (Other)
KW  - localized disease (Other)
KW  - relapsed disease (Other)
KW  - rhabdomyosarcoma (Other)
KW  - second-line chemotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37066598
DO  - DOI:10.1002/pbc.30363
UR  - https://inrepo02.dkfz.de/record/275451
ER  -