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000275452 041__ $$aEnglish
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000275452 1001_ $$0P:(DE-He78)9a08f3e289ddc5ed640e790e98e2f9ef$$aStreubel, Johanna$$b0$$eFirst author$$udkfz
000275452 245__ $$aControl of centrosome distal appendages assembly and disassembly.
000275452 260__ $$aAmsterdam$$bElsevier$$c2023
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000275452 520__ $$aCentrosomes are microtubule organizing centers involved in chromosome segregation, spindle orientation, cell motility and cilia formation. In recent years, they have also emerged as key modulators of asymmetric cell division. Centrosomes are composed of two centrioles that initiate duplication in S phase. The conservative nature of centriole duplication means that the two centrioles of a G1 cell are of different ages. They are also structurally different as only the older centriole carry appendages, an assembly of a subset of proteins primarily required for cilia formation. In a growing tissue, the non-motile, primary cilium acts as a mechano- and sensory organelle that influences cell behavior via modulation of signaling pathways. Here, we discuss the most recent findings about distal appendage composition and function, as well as cell cycle-specific regulation and their implications in various diseases.
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000275452 650_7 $$2Other$$aBasal body
000275452 650_7 $$2Other$$aCell cycle
000275452 650_7 $$2Other$$aCentriole maturation
000275452 650_7 $$2Other$$aCentrosome
000275452 650_7 $$2Other$$aCilia
000275452 650_7 $$2Other$$aDistal appendages
000275452 650_7 $$2Other$$aNEK2
000275452 650_7 $$2Other$$aPLK1
000275452 7001_ $$0P:(DE-He78)5138c10dcd0901d001d67a31423402b5$$aPereira, Gislene$$b1$$eLast author$$udkfz
000275452 773__ $$0PERI:(DE-600)3060825-9$$a10.1016/j.cdev.2023.203839$$gp. 203839 -$$p203839$$tCells & development$$v174$$x2667-2901$$y2023
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