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@ARTICLE{Streubel:275452,
      author       = {J. Streubel$^*$ and G. Pereira$^*$},
      title        = {{C}ontrol of centrosome distal appendages assembly and
                      disassembly.},
      journal      = {Cells $\&$ development},
      volume       = {174},
      issn         = {2667-2901},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00772},
      pages        = {203839},
      year         = {2023},
      note         = {DKFZ-ZMBH Alliance / 2023 Jun;174:203839/
                      #EA:A180#LA:A180#},
      abstract     = {Centrosomes are microtubule organizing centers involved in
                      chromosome segregation, spindle orientation, cell motility
                      and cilia formation. In recent years, they have also emerged
                      as key modulators of asymmetric cell division. Centrosomes
                      are composed of two centrioles that initiate duplication in
                      S phase. The conservative nature of centriole duplication
                      means that the two centrioles of a G1 cell are of different
                      ages. They are also structurally different as only the older
                      centriole carry appendages, an assembly of a subset of
                      proteins primarily required for cilia formation. In a
                      growing tissue, the non-motile, primary cilium acts as a
                      mechano- and sensory organelle that influences cell behavior
                      via modulation of signaling pathways. Here, we discuss the
                      most recent findings about distal appendage composition and
                      function, as well as cell cycle-specific regulation and
                      their implications in various diseases.},
      keywords     = {Basal body (Other) / Cell cycle (Other) / Centriole
                      maturation (Other) / Centrosome (Other) / Cilia (Other) /
                      Distal appendages (Other) / NEK2 (Other) / PLK1 (Other)},
      cin          = {A180},
      ddc          = {610},
      cid          = {I:(DE-He78)A180-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37062431},
      doi          = {10.1016/j.cdev.2023.203839},
      url          = {https://inrepo02.dkfz.de/record/275452},
}