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001     275452
005     20240229154941.0
024 7 _ |a 10.1016/j.cdev.2023.203839
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082 _ _ |a 610
100 1 _ |a Streubel, Johanna
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245 _ _ |a Control of centrosome distal appendages assembly and disassembly.
260 _ _ |a Amsterdam
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336 7 _ |a article
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500 _ _ |a DKFZ-ZMBH Alliance / 2023 Jun;174:203839/ #EA:A180#LA:A180#
520 _ _ |a Centrosomes are microtubule organizing centers involved in chromosome segregation, spindle orientation, cell motility and cilia formation. In recent years, they have also emerged as key modulators of asymmetric cell division. Centrosomes are composed of two centrioles that initiate duplication in S phase. The conservative nature of centriole duplication means that the two centrioles of a G1 cell are of different ages. They are also structurally different as only the older centriole carry appendages, an assembly of a subset of proteins primarily required for cilia formation. In a growing tissue, the non-motile, primary cilium acts as a mechano- and sensory organelle that influences cell behavior via modulation of signaling pathways. Here, we discuss the most recent findings about distal appendage composition and function, as well as cell cycle-specific regulation and their implications in various diseases.
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650 _ 7 |a Basal body
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650 _ 7 |a Cell cycle
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650 _ 7 |a Centriole maturation
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650 _ 7 |a Centrosome
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650 _ 7 |a Cilia
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650 _ 7 |a Distal appendages
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650 _ 7 |a NEK2
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650 _ 7 |a PLK1
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700 1 _ |a Pereira, Gislene
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773 _ _ |a 10.1016/j.cdev.2023.203839
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