%0 Journal Article
%A Mukama, Trasias
%A Srour, Bernard
%A Johnson, Theron
%A Katzke, Verena
%A Kaaks, Rudolf
%T IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases, and all-causes in EPIC - Heidelberg.
%J The journal of clinical endocrinology & metabolism
%V 108
%N 10
%@ 0368-1610
%C Oxford
%I Oxford University Press
%M DKFZ-2023-00776
%P e1092-e1105
%D 2023
%Z #EA:C020#LA:C020# / 2023 Sep 18;108(10):e1092-e1105
%X The functional status of organs involved in IGF-1 signalling pathways such as the liver influence circulating levels of IGF-1 and hence its relationship with risk of chronic diseases and mortality, yet has received limited attention.To examine the relationship between IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases and all-causes, accounting for liver function.Case-cohort design nested within EPIC-Heidelberg. IGF-1 was measured in 7,461 stored serum samples collected from 1994 to 1998. Median follow-up for incident mortality events: 17.5 years.General community.The case-cohort included a subcohort of 1,810 men and 1,890 women, in addition to 1668 incident cases of cancer (623 breast, 577 prostate, 202 lung and 268 colorectal cancers), and 1428 cases of CVD (707 MIs and 723 strokes) and 2441 cases of death.Higher IGF-1 levels showed direct associations with risks of breast (1.25 95
%K IGF-1 (Other)
%K cancer (Other)
%K cardiovascular diseases (Other)
%K liver enzymes (Other)
%K liver function (Other)
%K mortality (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37066827
%R 10.1210/clinem/dgad212
%U https://inrepo02.dkfz.de/record/275466