TY  - JOUR
AU  - Mukama, Trasias
AU  - Srour, Bernard
AU  - Johnson, Theron
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
TI  - IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases, and all-causes in EPIC - Heidelberg.
JO  - The journal of clinical endocrinology & metabolism
VL  - 108
IS  - 10
SN  - 0368-1610
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2023-00776
SP  - e1092-e1105
PY  - 2023
N1  - #EA:C020#LA:C020# / 2023 Sep 18;108(10):e1092-e1105
AB  - The functional status of organs involved in IGF-1 signalling pathways such as the liver influence circulating levels of IGF-1 and hence its relationship with risk of chronic diseases and mortality, yet has received limited attention.To examine the relationship between IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases and all-causes, accounting for liver function.Case-cohort design nested within EPIC-Heidelberg. IGF-1 was measured in 7,461 stored serum samples collected from 1994 to 1998. Median follow-up for incident mortality events: 17.5 years.General community.The case-cohort included a subcohort of 1,810 men and 1,890 women, in addition to 1668 incident cases of cancer (623 breast, 577 prostate, 202 lung and 268 colorectal cancers), and 1428 cases of CVD (707 MIs and 723 strokes) and 2441 cases of death.Higher IGF-1 levels showed direct associations with risks of breast (1.25 95
KW  - IGF-1 (Other)
KW  - cancer (Other)
KW  - cardiovascular diseases (Other)
KW  - liver enzymes (Other)
KW  - liver function (Other)
KW  - mortality (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37066827
DO  - DOI:10.1210/clinem/dgad212
UR  - https://inrepo02.dkfz.de/record/275466
ER  -