TY  - JOUR
AU  - Le Cornet, Charlotte
AU  - Jung, Audrey Ying-Chee
AU  - Johnson, Theron S
AU  - Behrens, Sabine
AU  - Obi, Nadia
AU  - Becher, Heiko
AU  - Chang-Claude, Jenny
AU  - Turzanski-Fortner, Renée
TI  - Postdiagnosis circulating osteoprotegerin and TRAIL concentrations and survival and recurrence after a breast cancer diagnosis: results from the MARIE patient cohort.
JO  - Breast cancer research
VL  - 25
IS  - 1
SN  - 1465-5411
CY  - London
PB  - BioMed Central
M1  - DKFZ-2023-00784
SP  - 42
PY  - 2023
N1  - #EA:C020#LA:C020#
AB  - Experimental studies suggest a role for osteoprotegerin (OPG) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in mammary tumor development and progression. These biomarkers have been minimally investigated with respect to outcomes in breast cancer patients.OPG and TRAIL were evaluated in blood samples collected from 2459 breast cancer patients enrolled in the MARIE study, a prospective population-based patient cohort, at median of 129 days after diagnosis. Participants were between ages 50 and 74 at diagnosis and recruited from 2002 to 2005 in two regions of Germany. Follow-up for recurrence and mortality was conducted through June 2015. Delayed-entry Cox proportional hazards regression was used to assess associations between OPG and TRAIL with all-cause and breast cancer-specific mortality, and recurrence, both overall and by tumor hormone receptor status.Median follow-up time was 11.7 years, with 485 deaths reported (277 breast cancer-specific). Higher OPG concentrations were associated with a higher risk of all-cause mortality (hazard ratio for 1-unit log2-transformed concentration (HRlog2) = 1.24 (95
KW  - Humans
KW  - Female
KW  - Middle Aged
KW  - Aged
KW  - Breast Neoplasms: pathology
KW  - Osteoprotegerin
KW  - Prospective Studies
KW  - Ligands
KW  - TNF-Related Apoptosis-Inducing Ligand
KW  - Tumor Necrosis Factor-alpha
KW  - Apoptosis
KW  - Biomarkers
KW  - Hormones
KW  - Breast cancer survival (Other)
KW  - Estrogen receptor status (Other)
KW  - OPG (Other)
KW  - TRAIL (Other)
KW  - Osteoprotegerin (NLM Chemicals)
KW  - Ligands (NLM Chemicals)
KW  - TNF-Related Apoptosis-Inducing Ligand (NLM Chemicals)
KW  - Tumor Necrosis Factor-alpha (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Hormones (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37069615
C2  - pmc:PMC10108482
DO  - DOI:10.1186/s13058-023-01625-4
UR  - https://inrepo02.dkfz.de/record/275477
ER  -