% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Maia:275479,
      author       = {A. Maia and Y. Cardona Gloria and K. Fuchs and T.-H. Chang
                      and P. Engels and M. Zhou and T. Hinnenthal and E. Rusch and
                      C. Gouttefangeas$^*$ and A. Weber$^*$},
      title        = {{C}hitin oligomers promote lymphoid innate and adaptive
                      immune cell activation.},
      journal      = {Journal of leukocyte biology},
      volume       = {114},
      number       = {2},
      issn         = {0741-5400},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-00786},
      pages        = {180-186},
      year         = {2023},
      note         = {2023 Jul 27;114(2):180-186},
      abstract     = {Chitin is a highly abundant N-acetyl-glucosamine (GlcNAc)
                      polysaccharide which has been linked to immune responses in
                      the context of fungal infections and allergic asthma,
                      especially to T helper 2 (Th2) immune responses.
                      Unfortunately, due to the frequent use of crude chitin
                      preparations of unknown purity and degree of polymerization,
                      there is still great uncertainty how chitin activates
                      different parts of the human immune system. We recently
                      identified chitin oligomers of six GlcNAc units as the
                      smallest immunologically active chitin motif and the innate
                      immune receptor TLR2 as a primary chitin sensor on human and
                      murine myeloid cells, but the response of further immune
                      cells, e.g. lymphoid cells, to oligomeric chitin has not
                      been investigated. Our analysis of primary human immune
                      cells now shows that chitin oligomers activate immune
                      responses of both innate and adaptive lymphocytes: Notably,
                      chitin oligomers activated Natural Killer (NK) cells but not
                      B lymphocytes. Moreover, chitin oligomers induced maturation
                      of dendritic cells and enabled potent CD8+ T cell recall
                      responses. Our results suggest that chitin oligomers not
                      only trigger immediate innate responses in a limited range
                      of myeloid cells, but also exert critical activities across
                      the entire human immune system. This highlights chitin
                      oligomer immune activation as an interesting and broadly
                      applicable potential target for both adjuvant development
                      and therapeutic interference in chitin-mediated
                      pathologies.},
      keywords     = {B cell (Other) / Chitin (Other) / N-acetyl-glucosamine
                      (Other) / Natural killer (NK) cell (Other) / T cell (Other)
                      / Toll-like receptor (TLR) (Other) / antigen-presenting cell
                      (Other) / lymphoid cell (Other) / myeloid cell (Other)},
      cin          = {TU01},
      ddc          = {570},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37075217},
      doi          = {10.1093/jleuko/qiad044},
      url          = {https://inrepo02.dkfz.de/record/275479},
}