TY  - JOUR
AU  - Mandic, Marko
AU  - Safizadeh, Fatemeh
AU  - Niedermaier, Tobias
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Association of Overweight, Obesity, and Recent Weight Loss With Colorectal Cancer Risk.
JO  - JAMA network open
VL  - 6
IS  - 4
SN  - 2574-3805
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2023-00795
SP  - e239556
PY  - 2023
N1  - #EA:C070#LA:C070#LA:C120#
AB  - Overweight and obesity, conditions with rising prevalence in many countries, are associated with increased colorectal cancer (CRC) risk. However, many patients with CRC lose weight before diagnosis, which may lead the association to be underestimated.To evaluate the association of body mass index (BMI) and weight change with CRC risk when considering BMI at different time frames, with the intention to account for prediagnostic weight loss.This population-based case-control study was conducted in southwestern Germany between 2003 and 2021. Cases with a first diagnosis of CRC and controls (frequency matched by age, sex, and county) with comprehensive risk factor information and self-reported weight at different time points were included. Data were analyzed between October 2022 and March 2023.BMI and weight change at different time frames before the time of diagnosis (cases) or recruitment (controls).Association of BMI and weight change at various points in time before and up to diagnosis with CRC, assessed by multivariable logistic regression with comprehensive confounder adjustment.A total of 11 887 participants (6434 CRC cases, 5453 controls; median [IQR] age, 69 [61-77] years; 7173 male [60.3
LB  - PUB:(DE-HGF)16
C6  - pmid:37083659
C2  - pmc:PMC10122181
DO  - DOI:10.1001/jamanetworkopen.2023.9556
UR  - https://inrepo02.dkfz.de/record/275584
ER  -