TY  - JOUR
AU  - Jones, Chris
AU  - Straathof, Karin
AU  - Fouladi, Maryam
AU  - Hargrave, Darren
AU  - Prados, Michael
AU  - Resnick, Adam
AU  - Doz, Francois
AU  - Jones, David T W
AU  - Mueller, Sabine
TI  - Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks.
JO  - Frontiers in oncology
VL  - 13
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-00805
SP  - 1167082
PY  - 2023
AB  - Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are underway across multiple international paediatric neuro-oncology consortia to take novel biological insights in the worst prognosis entities into innovative clinical trials. Whilst for the first time we are designing such studies on the basis of disease-specific biological data, the levels of preclincial evidence in appropriate model systems on which these trials are initiated is still widely variable. We have considered these issues between CONNECT, PNOC and ITCC-Brain, and developed a framework in which we can assess novel concepts being brought forward for possible clinical translation. Whilst not intended to be proscriptive for every possible circumstance, these criteria provide a basis for self-assessment of evidence by laboratory scientists, and a platform for discussion and rational decision-making prior to moving forward clinically.
KW  - CNS (Other)
KW  - in vitro (Other)
KW  - in vivo (Other)
KW  - models (Other)
KW  - pediatric (Other)
KW  - preclinical (Other)
KW  - translational (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37091147
C2  - pmc:PMC10114612
DO  - DOI:10.3389/fonc.2023.1167082
UR  - https://inrepo02.dkfz.de/record/275594
ER  -